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Metastatic Extramammary Paget's Disease : Pathogenesis and Novel Therapeutic Approach

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Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis. Recently, basic and translational investigative research has elucidated factors and molecular mechanisms underlying the promotion of metastasis, which can lead to targeted therapy-based emerging treatment strategies. Here, we aim to discuss current therapies and their limitations; advancements in illustrating mechanisms promoting invasion, migration, and proliferation of EMPD tumor cells; and future therapeutic approaches for metastatic EMPD that may enhance clinical outcomes.

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Detail Information

Series Title

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Call Number

616 FUK m

Publisher

: PubMed., 2018

Collation

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Language

English

ISBN/ISSN

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Classification

616

Content Type

text

Media Type

computer

Carrier Type

online resource

Edition

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Subject(s)

Paget's Disease

Specific Detail Info

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Statement of Responsibility

Keitaro Fukuda, Takeru Funakoshi

Other Information

Cataloger

maya

Source

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Validator

maya

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