Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to AÅ
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
This e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal …
In the age of neural networks and the Internet of Things (IoT), the search for new neural network architectures capable of operating on devices with limited computing power and small memory size is becoming an urgent agenda. This reprint focuses on recent developments in the organization of artificial intelligence (AI) on edge devices for various IoT-enabled smart applications and starts with t…
This open access volume provides an overview of the latest methods used to study neuronal function with all-optical experimental approaches, where light is used for both stimulation and monitoring of neuronal activity. The chapters in this book cover topics over a broad range, from fundamental background information in both physiology and optics in the context of all-optical neurophysiology exp…
The vertebrate brain contains neurons and 3 classical types of glia cells, astrocytes, oligodendrocytes and microglia. Astrocytes and microglia have mainly been studied in gray matter, whereas oligodendrocytes myelinate white matter tracts. Until recently microglial effects were considered mainly during pathological conditions, but is now known that microglia plays important roles also in norma…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King's College, Karolinska I…
This book provides the first comprehensive grammatical description of Choguita Rara?muri, a Uto-Aztecan language spoken in the Sierra Tarahumara, a mountainous range in the northern Mexican state of Chihuahua belonging to the Sierra Madre Occidental. A documentary corpus developed between 2003 and 2018 with Choguita Rara?muri language experts informs the analysis and is the source of the exampl…
This comprehensive open access book enables readers to discover the essential techniques for load forecasting in electricity networks, particularly for active distribution networks. From statistical methods to deep learning and probabilistic approaches, the book covers a wide range of techniques and includes real-world applications and a worked examples using actual electricity data (includi…