
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock an…

The first volume in this new text book series covers comprehensively relevant aspects related to the appearance and characterisation of fossil matter in the geosphere such as kerogen, oil, shales and coals. As organic geochemistry is a modern scientific subject characterized by a high transdisciplinarity and located at the edge of chemistry, environmental sciences, geology and biology, there cl…

The standard substrate complexation mechanism engages natural binding sites. In contrast, supramolecular structures may form complexes with proteins by penetrating in regions which are either naturally unstable or become temporarily accessible due to structural rearrangements related to the protein’s function. This may result in enhancement of irreversible processes (e.g. immune complexat…

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This thesis presents experimental and theoretical investigations of the connection between the time asymmetry in the short-time evolution of particle clusters and the intrinsic irreversibility of turbulent flows due to the energy cascade. The term turbulence describes a special state of a continuous medium in which many interacting degrees of freedom are excited. One of the interesting phen…

This book presents multivariate time series methods for the analysis and optimal control of feedback systems. Although ships’ autopilot systems are considered through the entire book, the methods set forth in this book can be applied to many other complicated, large, or noisy feedback control systems for which it is difficult to derive a model of the entire system based on theory in that subj…

This book starts with background concerning three-dimensional integration - including their low energy consumption and high speed image processing - and then proceeds to how to construct them and which materials to use in particular situations. The book covers numerous applications, including next generation smart phones, driving assistance systems, capsule endoscopes, homing missiles, and many…

In this Festschrift celebrating the career of Thom H. Dunning, Jr., selected researchers in theoretical chemistry present research highlights on major developments in the field. Originally published in the journal Theoretical Chemistry Accounts, these outstanding contributions are now available in a hardcover print format, as well as a special electronic edition. This volume provides valuable c…

The uncontrolled utilization of natural resources to supply to the water demands of the ever-growing population has brought about worldwide scarcity. The supply shortage has resulted in conflicts between countries, created prolonged drought, closing of industrial units, shifting of local inhabitants etc. The abnormality in climatic patterns due to global warming has only enhanced the uncertai…

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned edit…