This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essential…
This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and tran…
This concise guide to the often overlooked association between erectile dysfunction and hypertension/cardiovascular disease covers a wide range of aspects of importance to the clinician. It examines the impact of antihypertensive drug therapy on erectile function and explains how the management of erectile dysfunction in hypertensive patients depends on a variety of factors. Different treatment…
This volume provides a comprehensive review and detailed description of surgical techniques for prostate cancer surgery. All aspects are covered, including surgical anatomy and methods of transrectal ultrasound guided prostate biopsies, step-by-step approach techniques for radical prostatectomy, and the latest data on outcomes. Furthermore, limitations as well as tips and tricks are detailed in…
A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy an…
This volume provides practitioners with a practical, easy to read, well organized approach to the performance and analysis of urodynamics in order to optimize their usage clinically. Chapters are structured around specific types of patterns seen on urodynamic tracings. These urodynamic tracings are annotated and fully interpreted by the authors. Multiple examples of each type of tracing are pro…
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under v…
Thrombolytic therapy is finally starting to reach patients in a variety of settings all over the world. Formerly in the domain of sub-specialists, thrombolytic therapy now rests in the realm of Emergency Medicine, Intensive Care, Vascular, and Neuro hospital Medicine physicians. Increasingly, non-neurologists use thrombolytic therapy. This is a significant advancement since the 2nd edition to T…
This book describes contemporary clinical practice in the application of neurosurgical methods to the treatment of psychiatric disorders. It covers diverse topics such as neuroimaging, ethics and a historical review, Gamma Knife and High Frequency Ultrasound ablation, deep brain electrical stimulation and preoperative evaluation and postoperative follow-up. Its application in Obsessive Compulsi…
This is an up-to-date, comprehensive review of the neuropsychiatry of patients with movement disorders, i.e. Parkinson’s disease, Huntington’s disease, dystonia and others, by active authorities in the field, with an emphasis on diagnostic and management issues. This book includes critical appraisal of the methodological aspects and limitations of the current research on the neuropsychia…