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Translational Toxicology
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and poten…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-27449-2
- Collation
- XV, 380
- Series Title
- Molecular and Integrative Toxicology
- Call Number
- -
Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
- Edition
- 1
- ISBN/ISSN
- 978-1-4471-7032-7
- Collation
- XII, 312
- Series Title
- -
- Call Number
- -
Translational Neuropsychopharmacology
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-33911-5
- Collation
- XII, 498
- Series Title
- Current Topics in Behavioral Neurosciences
- Call Number
- -
Translating Molecular Biomarkers into Clinical Assays
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
- Edition
- 1
- ISBN/ISSN
- 978-3-319-40793-7
- Collation
- XIII, 212
- Series Title
- AAPS Advances in the Pharmaceutical Sciences Series
- Call Number
- -
Transglutaminases
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
- Edition
- 1
- ISBN/ISSN
- 978-4-431-55823-1
- Collation
- VIII, 391
- Series Title
- -
- Call Number
- -
Toxic Trauma
Winner of BMA Medical Book Award, Highly Commended in Public Health Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals a…
- Edition
- 2
- ISBN/ISSN
- 978-3-319-40916-0
- Collation
- XXIII, 238
- Series Title
- -
- Call Number
- -
Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacolo…
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the a…
- Edition
- Ed. 1
- ISBN/ISSN
- 978-3-319-41523-9
- Collation
- XIV, 403
- Series Title
- Handbook of Experimental Pharmacology
- Call Number
- 615 ADH a
Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell…
- Edition
- -
- ISBN/ISSN
- 978-3-658-10161-9
- Collation
- -
- Series Title
- -
- Call Number
- 615
A Toxicologist's Guide to Clinical Pathology in Animals: Hematology, Clinical…
This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studi…
- Edition
- Ed. 1
- ISBN/ISSN
- 978-3-319-15853-2
- Collation
- XVII, 151
- Series Title
- -
- Call Number
- 615 WHA t
A Systematic Review of Rural Development Research: Characteristics, Design Qu…
Rapid urbanisation, inequalities in income and service levels within and between communities, and population and economic decline are challenging the viability of rural communities worldwide. Achieving healthy and viable rural communities in the face of rapidly changing social, ecological and economic conditions is a declared global priority. As a result, governments all over the world, in both…
- Edition
- Ed. 1
- ISBN/ISSN
- 978-3-319-17284-2
- Collation
- X, 63
- Series Title
- SpringerBriefs in Public Health
- Call Number
- 615 EVA s
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