Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to AÅ
Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiologic…
An integrative rights-based approach to human development in Africa by Dejo Olowu 2009 ISBN: 978-0-9814124-6-7 Pages: x 322 Print version: Available Electronic version: Free PDF available
Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The compr…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
In the second half of the twentieth century, studies in Chinese painting history have been greatly aided by several major lists of Chinese artists and their works. Published between 1956 and 1980, these lists were limited to Imperial China. The current index covers the period from 1912 to around 1980. It includes the names of approximately 3,500 traditional-style artists along with lists of th…
A Historical Geography of Tourism in Victoria, Australia - Case studies is concerned with the emergence of tourism in colonial Victoria, Australia. It explores a fundamental set of questions: how does a tourist site come in to being? How does a tourist gaze emerge in a 'settler society'? How does an 'era of discovery' segue into 'tourism'? And, how was the tourist map of Victoria created by set…
As the first complete narrative in English of the Haitian Revolution, Marcus Rainsford's An Historical Account of the Black Empire of Hayti was highly influential in establishing nineteenth-century world opinion of this momentous event. This new edition is the first to appear since the original publication in 1805. Rainsford, a career officer in the British army, went to Haiti to recruit black …
Adhesive abilities of insects, spiders and reptiles have inspired researchers for a long time. All these organisms show outstanding performance, particularly for force, adhesion and climbing abilities, relative to their size and weight. Scientists have focused on the gecko's adhesive paw system and climbing abilities. Its adhesion mechanism has been an important topic of research for nearly 150…
The main objective of this volume is to diffuse the latest information related to hearing loss, which is among the most prevalent chronic disabilities worldwide. Nowadays, it is clear that the identification and rehabilitation of hearing impairment, when possible, have to be adequately and promptly managed because hearing loss can seriously interfere with psychosocial development, family dynami…