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Transglutaminases Multiple Functional Modifiers and Targets for New Drug Dis…
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
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- 978-4-431-55825-5
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The Essential Guide to N-of-1 Trials in Health
N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whet…
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- 1
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- 978-94-017-7200-6
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- XI, 245
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Continued Violence and Troublesome Pasts: Post-war Europe between the Victors…
In most European countries, the horrific legacy of 1939–45 has made it quite difficult to remember the war with much glory. Despite the Anglo-American memory narrative of saving democracy from totalitarianism and the Soviet epic of the Great Patriotic War, the fundamental experience of war for so many Europeans was that of immense personal losses and often meaningless hardships. The anthology…
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- 9789522229038
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The invasion of the Dutch East Indies
Between 1966 and 1980, the War History Office of the National Defense College of Japan published the 102-volume Senshi Sōsho (War History Series). These volumes give a detailed account of the operations of the Imperial Japanese Army and the Imperial Japanese Navy during the Second World War. This book, vol. 3 of the series, describes in depth the campaign to gain control over the Indonesian ar…
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- 9789400602298
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Toxicological Risk Assessment for Beginners
This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypot…
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- 978-3-319-12751-4
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Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of meta…
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- 978-3-319-15518-0
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Toxic Trauma A Basic Clinical Guide
Winner of BMA Medical Book Award, Highly Commended in Public Health Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals…
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- 978-3-319-40916-0
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Inflammatory Disorders
The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of …
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- 978-3-319-10011-1
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- X, 67
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- 615 INF
Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of…
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock an…
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- 978-4-431-55447-9
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Formulating Poorly Water Soluble Drugs
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physio…
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- 978-3-319-42609-9
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- XIV, 779 pages
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- AAPS Advances in the Pharmaceutical Sciences Series
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