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Genotoxicity and Carcinogenicity Testing of Pharmaceuticals
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emergin…
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- ISBN/ISSN
- 978-3-319-22083-3
- Collation
- X, 206
- Series Title
- -
- Call Number
- 616.9 GEN
Genomic Instability and Cancer Metastasis
Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotype…
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- ISBN/ISSN
- 978-3-319-12135-2
- Collation
- X, 247
- Series Title
- -
- Call Number
- 616.9 GEN
Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell…
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- ISBN/ISSN
- 978-3-658-10161-9
- Collation
- -
- Series Title
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- Call Number
- 615
Epigenetics Territory and Cancer
This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthro…
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- ISBN/ISSN
- 978-94-017-9639-2
- Collation
- 43 b/w illustrations, 53 illustrations in colour
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- -
- Call Number
- -
Epigenetic Advancements in Cancer
This volume explores the epigenetic alterations and their association with various human cancers. Considering one of human cancer as an example, individual chapters are focused on defining the role of epigenetic regulators and underlying mechanisms in cancer growth and progression. Epigenetic alteration including DNA methylation, histone modification, nucleosome positioning and non-coding R…
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- ISBN/ISSN
- 978-3-319-24951-3
- Collation
- 1 b/w illustrations, 11 illustrations in colour
- Series Title
- -
- Call Number
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Stress Response Pathways in Cancer
It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel boo…
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- ISBN/ISSN
- 978-94-017-9421-3
- Collation
- -
- Series Title
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- Call Number
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Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision…
This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by imp…
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- ISBN/ISSN
- 978-3-319-22189-2
- Collation
- X, 144 halaman
- Series Title
- -
- Call Number
- 616.994 PAN
Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.
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- ISBN/ISSN
- 978-3-319-45594-5
- Collation
- -
- Series Title
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PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible c…
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- ISBN/ISSN
- 978-3-319-14151-0
- Collation
- xix, 591 halaman
- Series Title
- Cancer Drug Discovery and Development
- Call Number
- 616.15 POL
General Methods in Biomarker Research and their Applications
Professor Victor R. Preedy is a senior faculty member of King's College London (Professor of Nutritional Biochemistry) and King's College Hospital (Professor of Clinical Biochemistry). He is attached to both the Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics. He is also Director of the Genomics Centre and a member of the School of Medicine. Professor Pr…
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- ISBN/ISSN
- 978-94-007-7695-1
- Collation
- -
- Series Title
- -
- Call Number
- 612.75
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