This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further secti…
This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authors’ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the …
E.F.F. Chladni’s experiments and observations with sound and vibrations profoundly influenced the development of the field of Acoustics. The famous Chladni diagrams along with other observations are contained in Die Akustik, published in German in 1802 and Traité d’Acoustique, a greatly expanded version, published in French in 1809. This is the first comprehensive translation of the expand…
This book provides an overview of recent developments in experiments probing the fractional quantum Hall (FQH) states of the second Landau level, especially the \nu=5/2 state. It summarizes the state-of-the-art understanding of these FQH states. It furthermore describes how the properties of the FQH states can be probed experimentally, by investigating tunneling and confinement properties. The …
The Fundamentals of Modern Astrophysics provides an overview of the modern science of astrophysics. It covers the Sun, Solar System bodies, exoplanets, stars, and star life cycle, planetary systems origin and evolution, basics of astrobiology, our galaxy the Milky Way, other galaxies and galactic clusters, a general view of the Universe, its structure, evolution and fate, modern views and advan…
This book provides readers with a concise introduction to current studies on operator-algebras and their generalizations, operator spaces and operator systems, with a special focus on their application in quantum information science. This basic framework for the mathematical formulation of quantum information can be traced back to the mathematical work of John von Neumann, one of the pioneers o…
This book reviews the phenomenology displayed by relativistic jets as well as the most recent theoretical efforts to understand the physical mechanisms at their origin. Relativistic jets have been observed and studied in Active Galactic Nuclei (AGN) for about half a century and are believed to be fueled by accretion onto a supermassive black hole at the center of the host galaxy. Since the firs…
These lecture notes present a concise and introductory, yet as far as possible coherent, view of the main formalizations of quantum mechanics and of quantum field theories, their interrelations and their theoretical foundations. The “standard” formulation of quantum mechanics (involving the Hilbert space of pure states, self-adjoint operators as physical observables, and the probabilisti…
This volume provides an overview of the fluid aspects of the climate system, focusing on basic aspects as well as recent research developments. It will bring together contributions from diverse fields of the physical, mathematical and engineering sciences. The volume will be useful to doctorate students, postdocs and researchers working on different aspects of atmospheric, oceanic and environme…
This book discusses a novel and high-rate-capable micro pattern gaseous detector of the Micromegas (MICRO-MEsh GAS detector) type. It provides a detailed characterization of the performance of Micromegas detectors on the basis of measurements and simulations, along with an in-depth examination of analysis and reconstruction methods. The accurate and efficient detection of minimum ionizing parti…