A sweeping exploration of essential concepts and applications in modern mathematics and science through the unifying framework of Fourier analysis! This unique, extensively illustrated book, accessible to specialists and non-specialists, describes the evolution of harmonic analysis, integrating theory and applications in a way that requires only some general mathematical sophistication and know…
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whet…
In most European countries, the horrific legacy of 1939–45 has made it quite difficult to remember the war with much glory. Despite the Anglo-American memory narrative of saving democracy from totalitarianism and the Soviet epic of the Great Patriotic War, the fundamental experience of war for so many Europeans was that of immense personal losses and often meaningless hardships. The anthology…
Between 1966 and 1980, the War History Office of the National Defense College of Japan published the 102-volume Senshi Sōsho (War History Series). These volumes give a detailed account of the operations of the Imperial Japanese Army and the Imperial Japanese Navy during the Second World War. This book, vol. 3 of the series, describes in depth the campaign to gain control over the Indonesian ar…
This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypot…
This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of meta…
Winner of BMA Medical Book Award, Highly Commended in Public Health Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals…
The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of …