The volume presents, in a synergistic manner, significant theoretical and practical contributions in the area of social media reputation and authorship measurement, visualization, and modeling. The book justifies and proposes contributions to a future agenda for understanding the requirements for making social media authorship more transparent. Building on work presented in a previous volume of…
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and poten…
This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these cond…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
Kita hidup di zaman yang disebut Big Data. Kami mendengar istilah seperti ilmuwan data, dan ada banyak pembicaraan tentang analitik dan penambangan data perusahaan dalam jumlah besar untuk informasi tentang nilai bisnis. Bahkan ada cerita apokrif yang melibatkan penjualan popok dan bir bersama di lorong toko yang sama. Tema umum adalah masalah memiliki data dalam jumlah besar dan entah bagaiman…
This book offers a re-assessment of the educational and occupational value of MOOCs based on developments since 2013. When MOOCs appeared--amidst great fanfare in 2012, leaders proclaimed an educational “revolution.” By 2013, however, dramatic failures, negative research findings, and sharp critiques ended the MOOC hype. This book examines both MOOCs and prior distance learning innovations,…
This book explores the relations between the EU and the BRICS in the areas of politics, economic development, trade and security. The contributions cover topics such as the position of the EU and BRICS in the global order and the EU as a "normative power," as well as the evolution, characteristics and institutionalization of BRICS and the roles of its member countries Brazil, Russia, India, Chi…
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
This thesis examines various aspects of excess excitation energy dissipation via dynamic changes in molecular structure, vibrational modes and solvation. The computational work is carefully described and the results are compared to experimental data obtained using femtosecond spectroscopy and x-ray scattering. The level of agreement between theory and experiment is impressive and provides both …