This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these cond…
Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Mos…
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology,…
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any,…
This book explores the concept of Life from a range of perspectives. Divided into three parts, it first examines the concept of Life from physics to biology. It then presents insights on the concept from the perspectives of philosophy, theology, and ethics. The book concludes with chapters on the hermeneutics of Life, and pays special attention to the Biosemiotics approach to the concept. The q…
This 32-chapter volume represents the core of several oral and poster presentations made at the conference. In addition to Introduction and Conclusion sections, the book is thematically divided into 7 sections, namely, 1) Land Use and Farming Systems, 2) Effects of Climate Change on Crop Yield, 3) Soil Nutrient and Water Management for Carbon Sequestration, 4) Rehabilitation of Degraded Lands …
The Conference on Traffic and Granular Flow brings together international researchers from different fields ranging from physics to computer science and engineering to discuss the latest developments in traffic-related systems. Originally conceived to facilitate new ideas by considering the similarities of traffic and granular flow, TGF'15, organised by Delft University of Technology, now cover…
This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essential…
This book provides a chronological introduction to the science of motion and rest based on the reading and analysis of significant portions of Galileo’s Dialogues Concerning Two New Sciences, Pascal’s Treatise on the Equilibrium of Fluids and the Weight of the Mass of Air, Newton’s Mathematical Principles of Natural Philosophy, and Einstein’s Relativity. Each chapter begins with a sh…