pendekatan kombinatorial untuk mengatasi tantangan seperti resistensi obat, atau kemanjuran yang kurang optimal. Pengembangan terapi kombinasi menghadapi beberapa tantangan: karakterisasi sinergi antara dua entitas kimia, definisi dosis yang tepat dan jadwal untuk memaksimalkan kemanjuran tanpa meningkatkan tingkat efek samping, yang meningkatkan tingkat kerumitannya secara signifikan. Untuk me…
Selama dekade terakhir, penulis buku ini telah bekerja sama erat dengan otoritas pengatur di banyak Pasar Negara Berkembang dan dengan Industri Farmasi untuk mengembangkan pemahaman yang lebih baik tentang aspirasi, hambatan, dan prioritas peraturan yang memengaruhi tinjauan dan ketersediaan. obat-obatan baru di luar wilayah ICH. Salah satu kunci menuju masa depan adalah kemungkinan Tinjauan Re…
Computational methods, and in particular quantum chemistry, have taken the lead in our growing understanding of noncovalent forces, as well as in their categorization. This volume describes the current state of the art in terms of what we now know, and the current questions requiring answers in the future. Topics range from very strong (ionic) to very weak (CH--π) interactions. In the intermed…
This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker t…
This straightforward guide to the administration of vaccines for travellers is intended to be the one-stop for the primary healthcare professional needing authoritative practical information speedily. In addition to basic knowledge in vaccinology, guides are offered as to appropriate vaccine recommendations for travel to global regions together with vaccine contents in order to identify any pre…
In the spirit of this road map, the author analyzes the post-election violence in Kenya from a legal point of view. He extensively examines legal options for domestic criminal accountability and discusses both retributive (prosecutions) and restorative justice (mainly truth commission) mechanisms, being the main legal responses to the gross violations of human rights. Furthermore, he thoroughly…
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the indiv…
This book is devoted exclusively to Lebesgue spaces and their direct derived spaces. Unique in its sole dedication, this book explores Lebesgue spaces, distribution functions and nonincreasing rearrangement. Moreover, it also deals with weak, Lorentz and the more recent variable exponent and grand Lebesgue spaces with considerable detail to the proofs. The book also touches on basic harmonic an…
Buku Metode Kimia dalam Penetration Enhancement: Modifikasi Stratum Korneum menjelaskan metode kimia yang digunakan dalam penetration enhancement obat-obatan dengan penekanan pada metode peningkat yang digunakan untuk memodifikasi stratum korneum. Ini dimulai dengan klasifikasi peningkat penetrasi, cara kerjanya, dan memberikan wawasan tentang hubungan struktur-aktivitas peningkat penetrasi ki…
Tujuan dari seri buku ini adalah untuk memberikan kepada pembaca yang bekerja di dunia akademis dan industri, termasuk peneliti muda, sebuah karya komprehensif terkini yang menjelaskan semua topik penting yang diperlukan untuk memahami prinsip-prinsip peningkatan pemberian obat transdermal dan dermal. Seri buku tersebut berisi lima buku. Buku Metode Kimia dalam Penetration Enhancement: Strategi…