This book elucidates how genetic, biological and medical information can be applied to the development of personalized healthcare, medication and therapies. Focusing on aspects of the development of evidence-based approaches in bioinformatics and computational medicine, including data integration, methodologies, tools and models for clinical and translational medicine, it offers an essential in…
This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequenci…
This book constitutes the proceedings of the 36th International Conference on Application and Theory of Petri Nets and Concurrency, PETRI NETS 2015, held in Brussels, Belgium, in June 2015. The 12 regular papers and 2 tool papers presented in this volume were carefully reviewed and selected from 34 submissions. In addition the book contains 3 invited talks in full paper length. The papers co…
Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiolo…
Apple Watch for Developers: Advice & Techniques from 5 Top Professionals gives you the base-knowledge and valuable secrets you'll need for your own projects from a core team of successful, experienced Apple Watch app-development experts. You'll explore elements such as branding within Watch apps, translating audio data into visual information, taming complex data, mastering environment-driven f…
This work exploits the natural experiment provided by the unexpected disintegration of socialist East Germany to study the impact of the mass immigration of East Germans on housing rents in West German metropolitan areas. Using a spatial correlation approach, annual district-level migration data for 1991 and 1992 and unique rental price indicators from Germany’s major regional property market…
This book provides various design techniques for switched-capacitor on-chip high-voltage generators, including charge pump circuits, regulators, level shifters, references, and oscillators. Readers will see these techniques applied to system design in order to address the challenge of how the on-chip high-voltage generator is designed for Flash memories, LCD drivers, and other semiconductor dev…
This book describes methods for distributing power in high speed, high complexity integrated circuits with power levels exceeding many tens of watts and power supplies below a volt. It provides a broad and cohesive treatment of power delivery and management systems and related design problems, including both circuit network models and design techniques for on-chip decoupling capacitors, providi…
This book enables readers to design effective ESD protection solutions for all mainstream RF fabrication processes (GaAs pHEMT, SiGe HBT, CMOS). The new techniques introduced by the authors have much higher protection levels and much lower parasitic effects than those of existing ESD protection devices. The authors describe in detail the ESD phenomenon, as well as ESD protection fundamentals, s…
Medical history offers us many wise thoughts, a few misguided notions, and a host of intriguing back-stories. On the Shoulders of Medicine’s Giants presents a selection of these, and tells how the words of medicine’s “giants”—such as Hippocrates, Sir William Osler, Francis Weld Peabody, and Elizabeth Kübler-Ross—are relevant to medical science and practice in the 21st century. Whi…