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Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of…
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock an…
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- 978-4-431-55447-9
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A Brief Narrative of an Unsuccessful Attempt to Reach Repulse Bay: Through Si…
This short work, featuring a number of attractive engravings, traces an abortive expedition to the Canadian Arctic. George Francis Lyon (1795–1832), naval officer and explorer, had accompanied William Parry on a previous expedition in search of the North-West Passage. In 1824 Lyon was instructed to return to Repulse Bay and to explore the mainland. Unfavourable weather conditions forced Lyon …
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- 9781107281202
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Topological States on Interfaces Protected by Symmetry
In this book, the author theoretically studies two aspects of topological states. First, novel states arising from hybridizing surface states of topological insulators are theoretically introduced. As a remarkable example, the author shows the existence of gapless interface states at the interface between two different topological insulators, which belong to the same topological phase. While…
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- 978-4-431-55534-6
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Topics on Methodological and Applied Statistical Inference
This book brings together selected peer-reviewed contributions from various research fields in statistics, and highlights the diverse approaches and analyses related to real-life phenomena. Major topics covered in this volume include, but are not limited to, bayesian inference, likelihood approach, pseudo-likelihoods, regression, time series, and data analysis as well as applications in the…
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- 978-3-319-44093-4
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Topics in Theoretical and Applied Statistics
This book highlights the latest research findings from the 46th International Meeting of the Italian Statistical Society (SIS) in Rome, during which both methodological and applied statistical research was discussed. This selection of fully peer-reviewed papers, originally presented at the meeting, addresses a broad range of topics, including the theory of statistical inference; data mining and…
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- 978-3-319-27274-0
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Foucault and Educational Ethics
In his works on ethics, Foucault turned towards an examination of one's relationship with oneself and others. This differs from the modern approaches that explore the relationship between and the responsibilities of actors to each other by adopting criteria. Ethical criteria engender assumptions about the actors by focusing on their responsibilities. Instead of relying on criteria, Foucault's w…
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- 978-1-137-57496-1
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- XIV, 112 pages
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Formulating Poorly Water Soluble Drugs
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physio…
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- 978-3-319-42609-9
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- XIV, 779 pages
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- AAPS Advances in the Pharmaceutical Sciences Series
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A Description of the Country from Thirty to Forty Miles round Manchester
The late eighteenth century saw Manchester and its surrounding areas undergo significant change as industrialisation fuelled urbanisation and population growth. In this classic 1795 account, the physician and prolific writer John Aikin (1747–1822) gathers together information on the settlements at the heart of manufacturing and trade in north-west England, covering the vital network of waterw…
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- 9781107706101
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- Cambridge Library Collection - British & Irish History, 17th & 18th Centuries
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Ethics for A-Level
What does pleasure have to do with morality? What role, if any, should intuition have in the formation of moral theory? If something is ‘simulated’, can it be immoral? This accessible and wide-ranging textbook explores these questions and many more. Key ideas in the fields of normative ethics, metaethics and applied ethics are explained rigorously and systematically, with a vivid writing st…
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- 9781783743902
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Graphic Design and Print Production Fundamentals
This textbook is written by a group of select experts with a focus on different aspects of the design process, from creation to production.Traditionally referred to as graphic design, communication design is the process by which messages and images are used to convey information to a targeted audience. It is within this spectrum that this textbook addresses the many steps of creating and then p…
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- 741.6 COL g
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