This book covers layout design and layout migration methodologies for optimizing multi-net wire structures in advanced VLSI interconnects. Scaling-dependent models for interconnect power, interconnect delay and crosstalk noise are covered in depth, and several design optimization problems are addressed, such as minimization of interconnect power under delay constraints, or design for minimal de…
Respiratory and cardiac motion leads to image degradation in Positron Emission Tomography (PET), which impairs quantification. In this book, the authors present approaches to motion estimation and motion correction in thoracic PET. The approaches for motion estimation are based on dual gating and mass-preserving image registration (VAMPIRE) and mass-preserving optical flow (MPOF). With mass-pre…
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by…
This book provides a comprehensive overview of key technologies being used to address challenges raised by continued device scaling and the extending gap between memory and central processing unit performance. Authors discuss in detail what are known commonly as “More than Moore” (MtM), technologies, which add value to devices by incorporating functionalities that do not necessarily scale a…
This volume contributes to debates about the teaching profession by reviewing international and national reports on its status, as well as on reforms of various education systems. It proposes a global approach to the quality of the teaching profession as a decisive ingredient of education quality, including a conception of its identity and a vision of its future. Moreover, it is suggested that …
This book presents topics on monitoring and evaluation of production processes in the automotive industry. Regulation of production processes is also described in details. The text deals with the implementation and evaluation of these processes during the mass production of components useful in the automotive industry. It evaluates the effects and results achieved after implementation in practi…
Cancer Biology, Medical Genetics, Cell Biology, Protein Biochemistry, Molecular Genetics
This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of th…
This book focuses on the current state of the art of the novel cold spray process. Cold spray is a solid state metal consolidation process, which allows engineers to tailor surface and shape properties by optimizing process parameters, powder characteristics and substrate conditions for a wide variety of applications that are difficult or impossible by other techniques. Readers will benefit fro…
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemist…