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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
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- 978-1-4471-4920-0
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Translational Neuroscience Fundamental Approaches for Neurological Disorders
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology,…
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- 978-1-4899-7654-3
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Translational Neuropsychopharmacology
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
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- 978-3-319-33913-9
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The Evolution of the Eye
With fascinating, spectacularly beautiful images, the book piques readers’ curiosity about the diversity of visual organs. This book is the result of a dual approach – scientific as well as aesthetic. The compelling images are accompanied by an easy-to-read, understandable text, aimed at both scientists and the educated public, and generally anyone interested in the beauty of nature. Thanks…
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- 978-3-319-17476-1
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- XVI, 214, 297 illustrations in colour
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The European Union in Crisis
This volume is a comprehensive and rigorous exploration of intertwined issues surrounding the EU's democracy and legitimacy, written in the turbulent context of the financial crisis. The chapters are woven together under four interconnected thematic sections that examine: rapidly growing national euroscepticism; the Economic Monetary Union and its legitimacy; the future of EU integration; and d…
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- 978-3-319-08774-0
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- XXI, 257, 12 b/w illustrations, 5 illustrations in colour
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Translational Approaches to Autism Spectrum Disorder
This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any,…
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- 978-3-319-16321-5
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Translating Molecular Biomarkers into Clinical Assays Techniques and Applica…
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
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- 978-3-319-40793-7
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Transition of the Yangtze River Delta From Global Manufacturing Center to Gl…
This is the first English book that presents a professional analysis of the recent dynamic movement of the Chinese economy by focusing on the Yangtze River Delta region, which is the main engine of the Chinese economy. The impact of the international financial crisis on China’s economic development requires a change from the first wave of economic globalization oriented toward exports to the …
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- 978-4-431-55178-2
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Transglutaminases Multiple Functional Modifiers and Targets for New Drug Dis…
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
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- 978-4-431-55825-5
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Transforming City Governments for Successful Smart Cities
There has been much attention paid to the idea of Smart Cities as researchers have sought to define and characterize the main aspects of the concept, including the role of creative industries in urban growth, the importance of social capital in urban development, and the role of urban sustainability. This book develops a critical view of the Smart City concept, the incentives and role of govern…
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- 978-3-319-03167-5
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