This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., …
Based on courses given at Eötvös Loránd University (Hungary) over the past 30 years, this introductory textbook develops the central concepts of the analysis of functions of one variable — systematically, with many examples and illustrations, and in a manner that builds upon, and sharpens, the student’s mathematical intuition. The book provides a solid grounding in the basics of logic an…
This is the book to focus on a new phenomenon emerging in the twenty-first century: the rapidly aging and decreasing population of a well-developed country, namely, Japan. The meaning of this phenomenon has been successfully clarified as the possible historical consequence of the demographic transition from high birth and death rates to low ones. Japan has entered the post-demographic transitio…
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text context…
This books discusses the design, electrical simulation and layout of a 2nd-order ∑∆ analog-to-digital converter (ADC), using oxide thin-film transistors (TFTs) technology. The authors provide a unified view of materials science and electronics engineering, in order to guide readers from both fields through key topics. To accomplish this goal, background regarding materials, device physics, …
The purpose of this introductory book is to couple the teaching of chaotic circuit and systems theory with the use of field programmable gate arrays (FPGAs). As such, it differs from other texts on chaos: first, it puts emphasis on combining theoretical methods, simulation tools and physical realization to help the reader gain an intuitive understanding of the properties of chaotic systems. …
How did the Commodore 64 conquer the hearts of millions and become a platform people still actively develop for even today? What made it so special? This book will appeal to both those who like tinkering with old technology as a hobby and nostalgic readers who simply want to enjoy a trip down memory lane. It discusses in a concise but rigorous format the different areas of home gaming and pe…
This book reviews the current state of information on reactive oxygen and nitrogen species and their role in cell communication during plant growth, development and adaptation to stress conditions. It addresses current research advances made in the area of reactive oxygen and nitrogen species (ROS and RNS) signaling. These free radical molecules are important in plant-microbe interactions, r…
The book systematically presents the theories of pseudo-differential operators with symbols singular in dual variables, fractional order derivatives, distributed and variable order fractional derivatives, random walk approximants, and applications of these theories to various initial and multi-point boundary value problems for pseudo-differential equations. Fractional Fokker-Planck-Kolmogorov e…
This well-known introductory textbook gives a uniform presentation of nuclear and particle physics from an experimental point of view. The first part, Analysis, is devoted to disentangling the substructure of matter. This part shows that experiments designed to uncover the substructures of nuclei and nucleons have a similar conceptual basis, and lead to the present picture of all matter bein…