This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/…
This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against…
This book is an introduction to the theory of Hilbert space, a fundamental tool for non-relativistic quantum mechanics. Linear, topological, metric, and normed spaces are all addressed in detail, in a rigorous but reader-friendly fashion. The rationale for an introduction to the theory of Hilbert space, rather than a detailed study of Hilbert space theory itself, resides in the very high mathem…
This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeuti…
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genom…
This book is a concise introduction to electromagnetics and electromagnetic fields that covers the aspects of most significance for engineering applications by means of a rigorous, analytical treatment. After an introduction to equations and basic theorems, topics of fundamental theoretical and applicative importance, including plane waves, transmission lines, waveguides and Green's functions, …
Fluorescence is the most popular technique in chemical and biological sensing and this book provides systematic knowledge of basic principles in the design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Its ultimate sensitivity, high temporal and spatial resolution and versatility enables high resolution imaging within living cells. It dev…
This book reports on a novel and comprehensive approach to the uptake of ICT in Schools. It focuses on key questions, pedagogically sound ways of introducing ICT, new technical artifacts supporting the approach, the evaluation in a large-scale validator, and future work. While many innovations in Technology Enhanced Learning (TEL) have emerged over the last two decades, the uptake of these inno…
This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, i…
The overall structure of this new edition is three-tier: Part I presents the basics, Part II is concerned with methodological issues, and Part III discusses advanced topics. In the second edition the authors have reorganized the material to focus on problems, how to represent them, and then how to choose and design algorithms for different representations. They also added a chapter on problems,…