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This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genom…
- Edition
- 1
- ISBN/ISSN
- 978-1-4939-3509-3
- Collation
- Biologi
- Series Title
- Advances in Experimental Medicine and Biology
- Call Number
- 570
Assessing Rare Variation in Complex Traits: Design and Analysis of Genetic St…
This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation an…
- Edition
- 1
- ISBN/ISSN
- 978-1-4939-2824-8
- Collation
- XI, 263
- Series Title
- -
- Call Number
- 573.21 ASS a
The Challenge of Chance A Multidisciplinary Approach from Science and the Hu…
Human Genetics; Philosophy of Science; Probability Theory
- Edition
- -
- ISBN/ISSN
- 9783319263007
- Collation
- -
- Series Title
- -
- Call Number
- -
Genetics of Diabetes Mellitus
Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabete…
- Edition
- 1
- ISBN/ISSN
- 978-1-4615-1597-5
- Collation
- XI, 250
- Series Title
- Endocrine Updates
- Call Number
- -
The Genetics of Diabetes Mellitus
On February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Göttingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Göttingen, and was generously sponsored by the Deutsche Forschungsgemeinschaft. Some forty geneticists and clinicians from Europe and N orth America, working in the field of diabetes bot…
- Edition
- 1
- ISBN/ISSN
- 978-3-642-66332-1
- Collation
- XI, 250
- Series Title
- -
- Call Number
- -
The Genetics of Type 2 Diabetes and Related Traits
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes. The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further secti…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-01574-3
- Collation
- XI, 576,40 b/w illustrations, 13 illustrations in colour
- Series Title
- -
- Call Number
- -
Immunopharmacogenomics
This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequenci…
- Edition
- -
- ISBN/ISSN
- 978-4-431-55725-8
- Collation
- IX, 162
- Series Title
- -
- Call Number
- 616 IMM
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