This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacteria…
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amin…
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemist…
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental princ…
Commemorating Morton Deutsch’s 95th birthday, this book presents ten major texts by this highly respected social psychologist on war and peace. This second volume presents Deutsch in his role as a leading social science activist on issues of war and peace – writing papers, making speeches and participating in demonstrations. After serving in the U.S. Air Force during World War II and being …
Commemorating Morton Deutsch’s 95th birthday, this book presents ten major texts by this highly respected social psychologist on war and peace. This first volume presents Deutsch in his role as a leading social science activist on issues of war and peace – writing papers, making speeches and participating in demonstrations. After serving in the U.S. Air Force during World War II and being a…
The tension between innovation and financialisation is central to the business corporation. Innovation entails a 'retain-and-reinvest' allocation regime that can form a foundation for stable and equitable economic growth.
This book offers a practical guide to the clinical management of sulphur and nitrogen mustard exposure including information on the history, pharmacology and toxicology of mustard compounds (MC). Basic and Clinical Toxicology of Mustard Compounds details the many resulting complications of sulphur mustard (SM) poisoning such as respiratory, Dermatological, Ophthalmological and Psychiatric. …
This textbook, now in its second edition, provides students with a firm grasp of the fundamental notions and techniques of applied mathematics as well as the software skills to implement them. The text emphasizes the computational aspects of problem solving as well as the limitations and implicit assumptions inherent in the formal methods. Readers are also given a sense of the wide variety of p…
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and poten…