This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome comp…
The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed vir…
The present work focuses on the diagnosis of TB, covering all its possible ways. Content ranges from clinical diagnosis, which is the first instance in approaching tuberculosis, until the gold standard microbiological and molecular diagnostic tools, which are useful due to its speed and high sensitivity. Additionally, diagnosis of latent TB infection, which is key feature to controlling TB unde…
This thesis presents a highly innovative study of the ultrafast structural and vibrational dynamics of hydrated phospholipids, the basic constituents of cell membranes. As a novel approach to the water-phospholipid interface, the author studies phosphate vibrations using the most advanced methods of nonlinear vibrational spectroscopy, including femtosecond two-dimensional infrared spectroscopy.…
Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand this pathogen and provi…
This Brief provides a comprehensive overview of Trypanosoma cruzi, a parasite that is traditionally considered as exclusively vectorborne, but can be foodborne, and may lead to outbreaks of Chagas disease in consumers. The characteristics of Trypanosoma cruzi and the clinical effects of the disease are covered, including documented outbreaks, regional patterns, and epidemiology. The various tra…
This volume investigates the effects of human activities on coral reefs, which provide important life-supporting systems to surrounding natural and human communities. It examines the self-reinforcing ecological, economic, and technological mechanisms that degrade coral reef ecosystems around the world. Topics include reefs and limestones in Earth history; the interactions between corals and the…
This book presents the latest information on tropical tree physiology, making it a valuable research tool for a wide variety of researchers. It is also of general interest to ecologists (e.g. Ecological Society of America; > 3000 or 4000 members at annual meeting), physiologists (e.g. American Society of Plant Biologists; > 2,000 members at annual meeting), and tropical biologists (e.g. Associa…
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just o…
This is the only introduction you'll need to start programming in R, the open-source language that is free to download, and lets you adapt the source code for your own requirements. Co-written by one of the R Core Development Team, and by an established R author, this book comes with real R code that complies with the standards of the language. Unlike other introductory books on the ground-brea…