This book constitutes the proceedings of the 12th International Conference on the Integration of Artificial Intelligence (AI) and Operations Research (OR) Techniques in Constraint Programming, CPAIOR 2015, held in Barcelona, Spain, in May 2015. The 29 papers presented together with 8 short papers in this volume were carefully reviewed and selected from 90 submissions. The purpose of the confere…
This is a thorough revision of the 2007 publication, and includes five new chapters and brings all existing chapters completely up to date. There have been many advances in hydropower and renewable technologies since the original publication, and Europe, and particularly Scandinavia, plan many more in the coming years. From a review of the original edition: “… it is important to …
This monograph, written by well renowned breast cancer expect, Dr. Jose Russo, provides new insight on the pathobiology of breast cancer from the most current advances in the field, translational research, initiation and progression of the disease, the mechanism of invasion and metastasis and the concept of stem cells in treatment and drug resistance. The role of personalized medicine and genom…
As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in…
This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open with an introduction contextualizing microRNA manipulation within today’s initiatives towards precision medicine. The following chapters exp…
This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Dis…
This volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis an…
This book provides a clearly structured introduction to hydrogen biology and medicine. Hydrogen is the one of the most abundant elements in the universe and has the simplest structure. In 2007, Japanese researchers found that the selective oxidation of hydrogen has a therapeutic effect on various diseases and injuries, sparking widespread interest in the biomedical field. In recent years, hundr…
This book provides a clearly structured introduction to hydrogen biology and medicine. Hydrogen is the one of the most abundant elements in the universe and has the simplest structure. In 2007, Japanese researchers found that the selective oxidation of hydrogen has a therapeutic effect on various diseases and injuries, sparking widespread interest in the biomedical field. In recent years, hundr…
Until researchers and theorists account for the complex relationship between resilience and culture, explanations of why some individuals prevail in the face of adversity will remain incomplete. This edited volume addresses this crucial issue by bringing together emerging discussions of the ways in which culture shapes resilience, the theory that informs these various studies, and important con…