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Kala Azar in South Asia: Current Status and Sustainable Challenges
Visceral leishmaniasis (VL), (also known as black fever or Kala-azar) is a life-threatening disease first reported from the Indian subcontinent. VL ranks as the world’s second largest parasitic disease killer and is a neglected tropical disease. Most of those infected by this life-threatening disease are uneducated daily wagers working to support their families, and vectors easily disseminate…
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- ISBN/ISSN
- 978-3-319-47101-3
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- -
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Global Existence and Uniqueness of Nonlinear Evolutionary Fluid Equations
This book presents recent results on nonlinear evolutionary fluid equations such as the compressible (radiative) magnetohydrodynamics (MHD) equations, compressible viscous micropolar fluid equations, the full non-Newtonian fluid equations and non-autonomous compressible Navier-Stokes equations. These types of partial differential equations arise in many fields of mathematics, but also in other …
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- ISBN/ISSN
- 978-3-0348-0593-3
- Collation
- XI, 211
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- Call Number
- 510 QIN g
Translational Toxicology
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and poten…
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- 1
- ISBN/ISSN
- 978-3-319-27449-2
- Collation
- XV, 380
- Series Title
- Molecular and Integrative Toxicology
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- -
Translational Research in Pain and Itch
This book provides a comprehensive review of the latest advances in translational pain and itch research, and presents the cutting-edge developments in the study of our two principal, yet most mysteries sensations. Despite the slow progress in the discovery of effective therapies for chronic pain and pruritus, scientists around the globe now have a better understanding of why and how these cond…
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- 1
- ISBN/ISSN
- 978-94-017-7535-9
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- XI, 147
- Series Title
- Advances in Experimental Medicine and Biology
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- -
Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
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- 1
- ISBN/ISSN
- 978-1-4471-7032-7
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- XII, 312
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- -
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Membrane Protein – Lipid Interactions: Physics and Chemistry in the Bilayer
This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions. A general introduction is presented in Chapters 1 and 2. The following Chapters, 3 and 4, describe the most accepted theories on lipid-membrane protein interactions as well as the new experime…
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- 1
- ISBN/ISSN
- 978-3-319-30275-1
- Collation
- XIV, 116
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- Membrane Protein – Lipid Interactions: Physics and Chemistry in the Bilayer
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- -
Translational Neuropsychopharmacology
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
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- 1
- ISBN/ISSN
- 978-3-319-33911-5
- Collation
- XII, 498
- Series Title
- Current Topics in Behavioral Neurosciences
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- -
Translating Molecular Biomarkers into Clinical Assays
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
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- 1
- ISBN/ISSN
- 978-3-319-40793-7
- Collation
- XIII, 212
- Series Title
- AAPS Advances in the Pharmaceutical Sciences Series
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- -
Transient Changes in Molecular Geometries and How to Model Them
This thesis examines various aspects of excess excitation energy dissipation via dynamic changes in molecular structure, vibrational modes and solvation. The computational work is carefully described and the results are compared to experimental data obtained using femtosecond spectroscopy and x-ray scattering. The level of agreement between theory and experiment is impressive and provides both …
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- 1
- ISBN/ISSN
- 978-3-319-18747-1
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- XXXVIII, 146
- Series Title
- Springer Theses
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Transglutaminases
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
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- 1
- ISBN/ISSN
- 978-4-431-55823-1
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- VIII, 391
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- -
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