Many breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease. Since the p…
This book systematically and comprehensively discusses the biological, epidemiological and clinical characteristics of the hepatitis E virus (HEV). It presents current knowledge of HEV and explores experimental methods, treatment and prevention of HEV. First identified in the 1980s and cloned in 1990, HEV is the causative agent of Hepatitis E, which mainly occurs in developing regions, such as …
Education for Sustainability is a key priority in today’s schools, as our society seeks to find a balance between environmental, social, cultural, political and economic imperatives that affect our future. As young children will become the next generation of adults, it is vital that they are educated about sustainability issues, so that they can learn to make informed decisions and take posit…
This is the first comprehensive review of the edge-to-edge technique for mitral repair, which was introduced into the surgical armamentarium in 1991 by one of the authors, Ottavio Alfieri. The surgical technique employed in edge-to-edge repair today provides the basis for the only reliable method of percutaneous correction of degenerative mitral regurgitation. The book traces the evolution of t…
This advanced undergraduate textbook is based on a one-semester course on single variable calculus that the author has been teaching at San Diego State University for many years. The aim of this classroom-tested book is to deliver a rigorous discussion of the concepts and theorems that are dealt with informally in the first two semesters of a beginning calculus course. As such, students are exp…
The book describes advanced business analytics and shows how to apply them to many different professional areas of engineering and management. Each chapter of the book is contributed by a different author and covers a different area of business analytics. The book connects the analytic principles with business practice and provides an interface between the main disciplines of engineering/techno…
This book constitutes the refereed proceedings of the 4th International Conference on Biologically Inspired Music, Sound, Art and Design, EvoMUSART 2015, held in Copenhagen, Denmark, in April 2015, co-located with the Evo* 2015 events EuroGP, EvoCOP and Evo Applications. The 23 revised full papers presented were carefully reviewed and selected from 43 submissions. They cover a wide range of top…
This book clearly shows the importance, usefulness, and powerfulness of current optimization technologies, in particular, mixed-integer programming and its remarkable applications. It is intended to be the definitive study of state-of-the-art optimization technologies for students, academic researchers, and non-professionals in industry. The chapters of this book are based on a collection of se…
This edited volume brings together academics from both innovation and marketing fields to explore the additional value for companies that can be generated with the innovations in marketing and the marketing of innovations. If ideas need to reach the marketplace, then marketing strategies, concepts and tools - such as the continuous development of new product and services - become vital for t…
This is the first book to cover GRASP (Greedy Randomized Adaptive Search Procedures), a metaheuristic that has enjoyed wide success in practice with a broad range of applications to real-world combinatorial optimization problems. The state-of-the-art coverage and carefully crafted pedagogical style lends this book highly accessible as an introductory text not only to GRASP, but also to combinat…