This book constitutes the proceedings of the second Asia Pacific Requirements Engineering Symposium, APRES 2015, held in Wuhan, China, in October 2015. The 9 full papers presented together with 3 tool demos papers and one short paper, were carefully reviewed and selected from 18 submissions. The papers deal with various aspects of requirements engineering in the big data era, such as automat…
This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cy…
This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms o…
This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignan…
This book explains why the climate change crisis is a symptom of a much larger underlying problem – namely, humankind’s predilection with continuous GDP-growth. Given this starting point, the world’s high-income nations must begin the transition to a qualitatively-improving steady-state economy and low-income nations must follow suit at some stage over the next 20-40 years. Unless they do…
This volume studies electron resonant tunneling in two- and three-dimensional quantum waveguides of variable cross-sections in the time-independent approach. Mathematical models are suggested for the resonant tunneling and develop asymptotic and numerical approaches for investigating the models. Also, schemes are presented for several electronics devices based on the phenomenon of resonant t…
Dealing with all aspects of Monte Carlo simulation of complex physical systems encountered in condensed-matter physics and statistical mechanics, this book provides an introduction to computer simulations in physics. This edition now contains material describing powerful new algorithms that have appeared since the previous edition was published, and highlights recent technical advances and key …
The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lav…
The book focuses on the contagion nature of respiratory ailments, the ways a pulmonary disease is spread. Respiratory infections are surrounded by interrelated circumstances that act upon individual and community and eventually underlie morbidity. Patient’s age, vulnerability to infections, immune function and responses, comorbidities, but also medical care and the agility in coping with stre…
The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the …