Translating Molecular Biomarkers into Clinical Assays

This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …

Transient Changes in Molecular Geometries and How to Model Them

This thesis examines various aspects of excess excitation energy dissipation via dynamic changes in molecular structure, vibrational modes and solvation. The computational work is carefully described and the results are compared to experimental data obtained using femtosecond spectroscopy and x-ray scattering. The level of agreement between theory and experiment is impressive and provides both …

Transglutaminases

This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015

Edition

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ISBN/ISSN

978-3-319-24573-7

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Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015:18t…

The three-volume set LNCS 9349, 9350, and 9351 constitutes the refereed proceedings of the 18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015, held in Munich, Germany, in October 2015. Based on rigorous peer reviews, the program committee carefully selected 263 revised papers from 810 submissions for presentation in three volumes. The papers…

Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015:18t…

The three-volume set LNCS 9349, 9350, and 9351 constitutes the refereed proceedings of the 18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015, held in Munich, Germany, in October 2015. Based on rigorous peer reviews, the program committee carefully selected 263 revised papers from 810 submissions for presentation in three volumes. The papers…

European Trend Atlas of Extreme Temperature and Precipitation Records

This Atlas presents records of climatic variability and change in Europe starting before 1901 and focuses especially on trends of extreme temperatures and precipitation. The authors have used software developed within EMULATE (European and North Atlantic daily to MULtidecadal climATE variability) to obtain the extremes indices and temporal trends. The trend atlas provides an easy way to identif…

European Perspectives on Behavioural Law and Economics

This anthology highlights the theoretical foundations as well as the various applications of Behavioural Law and Economics in European legal culture. By the same token, it fosters the dialogue between European and American Law and Economics scholars. The traditional neo-classical microeconomic theory explains human behaviour by using Rational Choice. According to this model, people tend to m…

Introduction to Computer Graphics

Introduction to Computer Graphics is a free, on-line textbook covering the fundamentals of computer graphics and computer graphics programming. This book is meant for use as a textbook in a one-semester course that would typically be taken by undergraduate computer science majors in their third or fourth year of college.

Global Aspects of Classical Integrable Systems

This book gives a uniquely complete description of the geometry of the energy momentum mapping of five classical integrable systems: the 2-dimensional harmonic oscillator, the geodesic flow on the 3-sphere, the Euler top, the spherical pendulum and the Lagrange top. It presents for the first time in book form a general theory of symmetry reduction which allows one to reduce the symmetries in th…