This atlas is currently the most systematic and comprehensive atlas of the tree shrew brain. The purpose of this book is to help scientists acquire accurate coordinates of the brain regions of the tree shrew, which is becoming a popular animal model for a variety of human diseases. This atlas contains series of 192 coronal sections, 36 sagittal sections, and 49 horizontal sections using Nissl s…
The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is co…
The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but a…
Overview: Like most introductory science textbooks, this one opens with a discussion of scientific method. A key feature is its focus on experimental support for what we know about cell and molecular biology. Understanding how science is practiced and how investigators think about experimental results is essential to understanding the relationship of cell structure and function…, not to menti…
This textbook provides a collection of case studies in paleoanthropology demonstrating the method and limitations of science. These cases introduce the reader to various problems and illustrate how they have been addressed historically. The various topics selected represent important corrections in the field, some critical breakthroughs, models of good reasoning and experimental design, and im…
This book offers a new explanation for the development of flight in mammals and offers detailed morphological descriptions of mammals with flapping flight. The skeletomuscular apparatus of the shoulder girdle and forelimbs of tree shrews, flying lemurs and bats is described in detail. Special attention is paid to the recognition of peculiar features of the skeleton and joints. For the basic loc…
This volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics—the mechanics of the tumor cells as they arise and spread throughout the body—and oncodynamics—the impact of abnormal cues generated by tumors on the physiological functioning of the body. The volume will outline the importance of oncodynamics from both a cancer patient’s and a caregive…
The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives an…
This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and dis…
This book provides an overview of microgravity-induced changes in human metabolism, muscle, bone and the cardio-vascular system, and discusses in detail the nutrient uptake required during spaceflight to counteract these adaptive mechanisms and ensure an improved physical constitution upon returning to Earth. It addresses the needs of professors, researchers and students working in the field of…