The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the m…
This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explo…
This book presents a collection of expert reviews on different subcellular compartments of the cardiomyocyte, addressing fundamental questions such as how these compartments are assembled during development, how they are changed in and by disease and which signaling pathways have been implicated in these processes so far. As such, it offers the first overview of the cell biology of heart diseas…
This handbook is an ideal, up-to-date guide to the application of catheter-based interventions across the entire patient age range, from fetal life through to adulthood. Clear instruction is offered on techniques of vascular access, valve dilatation, angioplasty, stent implantation, defect closure, defect creation, pulmonary valve implantation and the hybrid approach, as well as miscellaneous o…
This second edition is adheres to the guiding principles of the first edition while serving as a useful and up to date manual on the theory, performance and application of CCTA. Since the publication of the first edition of this work, cardiac CT angiography (CCTA) has come a long way. It is now a main stream, well established cardiac diagnostic imaging modality with wide spread acceptance and a…
Drawing on extensive ethnographic fieldwork, this study explores the ideas of belonging and citizenship among former pro-autonomy East Timorese who have elected to settle indefinitely in West Timor. The study follows different East Timorese groups and examines various ways they construct and negotiate their socio-political identities following the violent and destructive separation from their h…
This book reveals why carbon is playing such an increasingly prominent role as a sensing material. The various steps that transform a raw material in a sensing device are thoroughly presented and critically discussed. The authors deal with all aspects of carbon-based sensors, starting from the various hybridization and allotropes of carbon, with specific focus on micro and nano sized carbons (e…
This book is the result of a longitudinal research project (2016–2018) funded by the National Research Foundation and the Fuchs Foundation, and it disseminates original research. The project researched the affordances of indigenous knowledge in the school science, technology and mathematics curricula. Short learning programmes (SLPs) were offered to STEM teachers, during which they engaged in…
The central theme of this volume is the work of Sabahattin Ali, the Turkish author and translator from German into Turkish who achieved posthumous success with his novel Kürk Mantolu Madonna (The Madonna in the Fur Coat). Our contributors analyze this novel, which takes place largely in Germany, and several other texts by Ali in the context of world literature, (cultural) translation, and inte…
Recent findings on phonetic detail have been taken as supporting exemplar-based approaches to prosody. Through four experiments on both produc tion and perception of both melodic and temporal detail in Neapolitan Italian, we show that prosodic detail is not incompatible with abstractionist approaches either. Specifically, we suggest that the exploration of prosodic detail leads to a refined und…