Choosing an uncemented femoral prosthesis means first choosing a concept and to be effective, an operator has to have access to all the information that will allow them to reach the desired goals. This is the first step to be made. The quality of a surgical procedure does not depend on the manual skills of the surgeon performing it, but on how he has prepared and performed the operation “v…
This book describes the process of completing an NIH R01 grant application. It begins with the formation of an idea and proceeds through the subsequent stages: verifying the idea’s strength and potential, collecting high-quality preliminary data, networking for feedback, writing the first and subsequent drafts of the application (including details on what to include and tips on content and t…
Individual turnpike results are of great interest due to their numerous applications in engineering and in economic theory; in this book the study is focused on new results of turnpike phenomenon in linear optimal control problems. The book is intended for engineers as well as for mathematicians interested in the calculus of variations, optimal control and in applied functional analysis. Two…
This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration betw…
The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagn…
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacteria…
This monograph deals with theoretical and practical aspects of creating course timetables at academic institutions. The task is typically to create a timetable that suits the requirements of the stakeholders – students, lecturers, and the administration – as well as possible. The book presents an exposition of the basic combinatorial problems and solution methods for course timetabling and …
This monograph provides a detailed analysis on fair queueing rules from a normative, a strategic, and a non-cooperative viewpoint. The queueing problem is concerned with the following situation: There is a group of agents who must be served in a facility. The facility can handle only one agent at a time and agents incur waiting costs. The problem is to find the order in which to serve agents an…
This book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS, FXPOI and their families, as well as presenting the molecular basis for disease that may lead to the identification of new markers to predict disease risk and eventually lead to target treatments. The book will present information on all aspects of FXTA…
This book offers a thorough and systematic introduction to the modified failure mode and effect analysis (FMEA) models based on uncertainty theories (e.g. fuzzy logic, intuitionistic fuzzy sets, D numbers and 2-tuple linguistic variables) and various multi-criteria decision making (MCDM) approaches such as distance-based MCDM, compromise ranking MCDM and hybrid MCDM, etc. As such, it provides e…