Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy…
South American ecosystems suffered one of the greatest biogeographical events, after the establishment of the Panamian land bridge, called the “Great American Biotic Interchange” (GABI). This refers to the exchange, in several phases, of land mammals between the Americas; this event started during the late Miocene with the appearance of the Holartic Procyonidae (Huayquerian Age) in South Am…
This book seeks to provide a comprehensive reconstruction of the 1667 Dalmatia earthquake phenomenon on the basis of eyewitness testimony. At the same time, one of the distinctive features of this book is that the earthquake observations are treated and arranged in time and space so as to provide earthquake data on the macroseismic intensity, which might be used in seismic hazard and risk studi…
This book gives a comprehensive treatment of the Grassmannian varieties and their Schubert subvarieties, focusing on the geometric and representation-theoretic aspects of Grassmannian varieties. Research of Grassmannian varieties is centered at the crossroads of commutative algebra, algebraic geometry, representation theory, and combinatorics. Therefore, this text uniquely presents an exciting …
This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes…
The most comprehensive guide on postgraduate grants and professional funding globally. For thirty-two years it has been the leading source for up-to-date information on the availability of, and eligibility for, postgraduate and professional awards. Each entry is verified by its awarding body and all information is updated annually.
The English language volume offers a current stock-take of central areas in adult and vocational further education in France. The author Silke Schreiber-Barsch bases her work on various types of data and information. Beginning with historical developments, Schreiber-Barsch covers the topics of political, financial and institutional framework conditions, as well as offer, participation and teach…
Elite level sport lends itself to a highly competitive environment that encourages players to seek a competitive advantage in order to win. Since competition is an inherent condition that is also considered desirable in this setting, it may at first glance seem as if cooperation does not have any room in elite level sports. Sustainable cooperation can be mutually advantageous for players, but i…
Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by su…
This book is a brief primer covering concepts central to digital imagery, digital audio and digital illustration using open source software packages such as GIMP, Audacity and Inkscape. These are used for this book because they are free for commercial use. The book builds on the foundational concepts of raster, vector and waves (audio), and gets more advanced as chapters progress, covering what…