This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by…
This proceedings volume contains a selection of invited and contributed papers of the 9th International Workshop on Sulfur Metabolism in Plants, which was hosted by Heinz Rennenberg, Albert-Ludwigs-University Freiburg and was held at Schloss Reinach, Freiburg-Munzigen, Germany from April 14-17, 2014. The focus of this workshop was on molecular physiology and ecophysiology of sulfur in plants an…
This book outlines a unified theory of embryonic development, assuming morphogenesis to be a multi-level process including self-organizing steps while also obeying general laws. It is shown how molecular mechanisms generate mechanical forces, which in the long run lead to morphological changes. Questions such as how stress-mediated feedback acts at the cellular and supra-cellular levels and ho…
This contributed volume aims to reconsider the concept of individuation, clarifying its articulation with respect to contemporary problems in perceptual, neural, developmental, semiotic and social morphogenesis. The authors approach the ontogenetical issue by taking into account the morphogenetic process, involving the concept of individuation proposed by Gilbert Simondon and Gilles Deleuze. Th…
Movies will never be the same after you learn how to analyze movie data, including key data mining, text mining and social network analytics concepts. These techniques may then be used in endless other contexts. In the movie application, this topic opens a lively discussion on the current developments in big data from a data science perspective. This book is geared to applied researchers and pr…
This work pursues a novel route to functionalizing large surfaces with hybrid nanoparticles. It also casts new light on the combined use of surface plasmon resonance and X-rays. SPR spectroscopy is employed to study Au-based plasmonic nanostructures fabricated by novel methods, and a new experimental device is developed combining SPR with X-ray absorption spectroscopy at a synchrotron beamline.…
In the last few years modified gravity theories have been proposed as extensions of Einstein's theory of gravity. Their main motivation is to explain the latest cosmological and astrophysical data on dark energy and dark matter. The study of general relativity at small scales has already produced important results (cf e.g. LNP 863 Quantum Gravity and Quantum Cosmology) while its study at large …
This book provides a general introduction to the rapidly developing astrophysical frontier of stellar tidal disruption, but also details original thesis research on the subject. This work has shown that recoiling black holes can disrupt stars far outside a galactic nucleus, errors in the traditional literature have strongly overestimated the maximum luminosity of “deeply plunging” tidal di…
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.The book is divided into four parts; the first deals with the fundamental principle…