This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any,…
This book presents an overview of modeling definitions and concepts, theory on human behavior and human performance data, available tools and simulation approaches, model development, and application and validation methods. It considers the data and research efforts needed to develop and incorporate functions for the different parameters into comprehensive escape and evacuation simulations, wit…
This book presents lessons learnt from Japan’s past, in relation to coastal waters, industrial pollutants and concentrated urban populations. It examines ecosystem damage and pollution in coastal sea areas and addresses the question: What is the present status of Japanese estuaries from the view point of eutrophication and oligotrophication? The authors describe three typical situations, name…
This book provides clear instruction on the surgical treatment of joint problems in adult hemophilia patients. The procedures applicable to specific joints, including the shoulder, elbow, hip, knee and ankle, are carefully reviewed with the aid of high-quality illustrations. The surgical treatment of articular hemophilic pseudotumors and bone cysts is also considered. In addition, clinically re…
This book presents a comprehensive history of the many contributions the Jesuits made to science from their founding to the present. It also links the Jesuits dedication to science with their specific spirituality which tries to find God in all things. The book begins with Christopher Clavius, professor of mathematics in the Roman College between 1567 and 1595, the initiator of this tradition. …
This book celebrates the 100th birthday of Jerome S. Bruner, one of the most relevant scholars in contemporary psychology. It shows how Bruner’s oeuvre and contributions to psychology, education and law are still applicable today and full of unexplored possibilities. The volume brings together contributions from Bruner’s students and colleagues, all of whom use his legacy to explore the fut…
This Atlas presents records of climatic variability and change in Europe starting before 1901 and focuses especially on trends of extreme temperatures and precipitation. The authors have used software developed within EMULATE (European and North Atlantic daily to MULtidecadal climATE variability) to obtain the extremes indices and temporal trends. The trend atlas provides an easy way to identif…
This anthology highlights the theoretical foundations as well as the various applications of Behavioural Law and Economics in European legal culture. By the same token, it fosters the dialogue between European and American Law and Economics scholars. The traditional neo-classical microeconomic theory explains human behaviour by using Rational Choice. According to this model, people tend to m…
The work addresses the following questions in the context of interglacial climate dynamics: (i) What are the amplitudes of natural climate variations on timescales of several years to millennia? (ii) Do abrupt changes in the large-scale circulation of the Atlantic Ocean occur in interglacials? (iii) Which biogeochemical feedback mechanisms control the natural limits of atmospheric concentration…