Translational Research is the interface between basic science and human clinical application, including the entire process from animal studies to human clinical trials (phases I, II, and III). Translational Research moves promising basic science results from the laboratory to bedside application. Yet, this transition is often the least-defined, least-understood part of the research process. Mos…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology,…
This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importa…
Networks are everywhere: networks of friends, transportation networks and the Web. Neurons in our brains and proteins within our bodies form networks that determine our intelligence and survival. This modern, accessible textbook introduces the basics of network science for a wide range of job sectors from management to marketing, from biology to engineering, and from neuroscience to the social …
GNU / Linux (https://www.gnu.org/gnu/linux-and-gnu.html) adalah blok bangunan dasar Internet. Banyak situs Internet yang paling banyak dikunjungi menjalankan beberapa rasa GNU / Linux. Bersama dengan GNU / Linux adalah perangkat lunak bebas dan sumber terbuka lainnya yang digunakan untuk membangun infrastruktur bagi organisasi. Buku ini berfungsi sebagai panduan bagi para insinyur yang ingin me…
Mathematical Analysis (often called Advanced Calculus) is generally found by students to be one of their hardest courses in Mathematics. This text uses the so-called sequential approach to continuity, differentiability and integration to make it easier to understand the subject.Topics that are generally glossed over in the standard Calculus courses are given careful study here. For example, wha…
Driving Change tells a story that exemplifies a basic law of physics, known to all, the application of a relatively small lever can shift weight, create movement and initiate change far in excess of its own size. It tells a story about a particular instance of development cooperation, relatively modest in scope and aim that has nonetheless achieved remarkable things and has been held up as an e…
It is uncontroversial that corporations are legal agents that can be held legally responsible, but can corporations also be moral agents that are morally responsible? Part one of this book explicates the most prominent theories of corporate moral agency and provides a detailed debunking of why corporate moral agency is a fallacy. This implies that talk of corporate moral responsibilities, beyon…
Kita hidup di zaman yang disebut Big Data. Kami mendengar istilah seperti ilmuwan data, dan ada banyak pembicaraan tentang analitik dan penambangan data perusahaan dalam jumlah besar untuk informasi tentang nilai bisnis. Bahkan ada cerita apokrif yang melibatkan penjualan popok dan bir bersama di lorong toko yang sama. Tema umum adalah masalah memiliki data dalam jumlah besar dan entah bagaiman…