This book builds a much-needed bridge between biostatistics and organismal biology by linking the arithmetic of statistical studies of organismal form to the biological inferences that may follow from it. It incorporates a cascade of new explanations of regression, correlation, covariance analysis, and principal components analysis, before applying these techniques to an increasingly common dat…
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, tak…
This successful textbook on predictive text mining offers a unified perspective on a rapidly evolving field, integrating topics spanning the varied disciplines of data science, machine learning, databases, and computational linguistics. Serving also as a practical guide, this unique book provides helpful advice illustrated by examples and case studies. This highly anticipated second edition has…
This work sheds new light on fundamental aspects of phase separation in polymer-blend thin films. A key feature underlying the theoretical models is the unification of one-dimensional thermodynamic phase equilibria with film evolution phenomena in two- and three dimensions. Initially, an established 'phase portrait' method, useful for visualising and calculating phase equilibria of polymer-blen…
This book provides a conceptual and computational framework to study how the nervous system exploits the anatomical properties of limbs to produce mechanical function. The study of the neural control of limbs has historically emphasized the use of optimization to find solutions to the muscle redundancy problem. That is, how does the nervous system select a specific muscle coordination pattern w…
This book, first published in 2004, provides an introduction to the major mathematical structures used in physics today. It covers the concepts and techniques needed for topics such as group theory, Lie algebras, topology, Hilbert space and differential geometry. Important theories of physics such as classical and quantum mechanics, thermodynamics, and special and general relativity are also de…
Designed for one-semester courses at the senior undergraduate level, this 2003 book will appeal to mathematics undergraduates, to mathematics teachers, and to others who need to learn some mathematical analysis for use in other areas such as engineering, physics, biology or finance. Topics such as completeness and compactness are approached initially through convergence of sequences in metric s…
This preamble sets out to introduce the topic of international procedural law, focusing on the intellectual history of international dispute settle- ment. The leading idea is to take a picture of the major contributions to the reflection on international procedural law, starting from some mile- stone works which developed the basic ideas, the epistemic grounds of an international procedura…
This book investigates lifecycle management strategies used by pharmaceutical companies attempting to maximize the value of their product portfolio. Such strategies are sometimes referred to by generic drug companies as “evergreening”. The analysis focuses on two of these strategies, namely product improvements and product line extensions. In particular, an evaluation of the patents that fo…
This concise introduction to model theory begins with standard notions and takes the reader through to more advanced topics such as stability, simplicity and Hrushovski constructions. The authors introduce the classic results, as well as more recent developments in this vibrant area of mathematical logic. Concrete mathematical examples are included throughout to make the concepts easier to foll…