This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes…
This book introduces analytical ultracentrifugation (AUC) as a whole, covering essential theoretical and practical aspects as well as its applications in both biological and non-biological systems. Comprehensive characterizations of macromolecules in a solution are now routinely required not only for understanding the solution system but also for producing a solution with better properties. Ana…
This text provides both review and primary research articles for a broad audience of biologists, chemists, biochemists, pharmacologists, clinicians and nutrition experts, especially those interested in the biosynthesis, structure, function and/or bioactivity of plant natural products. Recurring themes include the evolution and ecology of specialized metabolites, the genetic and enzymatic mechan…
This book offers an up-to-date review of the regulatory role of nitric oxide (NO) changes in the morphological, physio-biochemical as well as molecular characteristics of plants under abiotic stress. The first of two parts comprises four chapters and focuses on the properties, chemical reactions involving NO and reactive nitrogen species in plants. The second part, consisting of eleven chapters…
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane p…
Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. Th…
Diabetes mellitus is a group of metabolic disorders leading to defects in insulin se- cretion and action of insulin or both. Diabetes is caused by a combination of hereditary and environmental factors. In the human body, blood glucose levels are controlled by a complex interaction of multiple chemicals and hormones, including insulin and glucagon. Insulin is a peptide hormone produced in …
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT). 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as …
This book provides an up-to-date overview of redox signaling in plant cells and its key role in responses to different stresses. The chapters, which are original works or reviews, focus on redox signaling states; cellular tolerance under different biotic and abiotic stresses; cellular redox homeostasis as a central modulator; redox homeostasis and reactive oxygen species (ROS); redox balance in…
Interest in the study of life in hot environments, both with respect to the inhabiting microorganisms and the enzymes they produce, is currently very high. The biological mechanisms responsible for the resistance to high temperatures are not yet fully understood, whereas thermostability is a highly required feature for industrial applications. In this e-book, the invited authors provide diverse…