This book addresses and synthesizes recent basic, translational, and clinical research with the goal of understanding the mechanisms behind autism spectrum disorder (ASD) and how they lead to altered brain function and behavior. Bringing clarity to these mechanisms will lead to more effective therapies for the various heterogeneous pathologies that comprise ASD. Currently there are few, if any,…
Cerebral visual disorders have far-reaching consequences for child development. These have profound adverse effects on children’s education and success in school and also in later life, but, unfortunately, cerebral visual disorders often remain undiagnosed and untreated in the pediatric population. This book provides a state-of-the-art account of what is known about the development and disord…
This book demonstrates that the systematic study of gene expression patterns in embryonic and adult brains, in combination with selected data from earlier studies, can pave the way for a new neuromorphology, the most salient features of which may be summarized as follows: (1) Causal analysis of molecular patterning at neural plate and early neural tube stages has shown that the CNS is essential…
Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addi…
This book provides the practicing physician with a practical approach to the diagnosis, evaluation and management of headache disorders based on lessons learned from real-life headache patients. Internationally well-known headache experts present cases from their own practice and discuss the evaluation and management of each case step by step. The clearly structured chapters cover initial evalu…
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under v…
Thrombolytic therapy is finally starting to reach patients in a variety of settings all over the world. Formerly in the domain of sub-specialists, thrombolytic therapy now rests in the realm of Emergency Medicine, Intensive Care, Vascular, and Neuro hospital Medicine physicians. Increasingly, non-neurologists use thrombolytic therapy. This is a significant advancement since the 2nd edition to T…
Every neurosurgeon as well as many surgeons in other disciplines, including plastic and orthopedic surgeons, may unexpectedly be confronted with an entrapment syndrome or a nerve trauma. With a view to preventing costly transfers to expert clinics, this manual for practitioners offers optimized step-by-step figures illustrating how best to approach every relevant nerve lesion. Clear advice is a…
This book describes the specific surgical techniques currently employed in patients with intractable epilepsy; it also covers the relevant technical aspects of general neurosurgery. All of the approaches associated with the various foci of epilepsy within the cerebral hemispheres are considered, including temporal and frontal lobectomies and corticectomies, parietal and occipital lobe resection…
Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The fi…