Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5 °C is one of the most common treatments in HIE and generally improves outcome; however 45–55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabol…
Computer networking & communications
"This book examines the key dimensions of 21st century war, and shows that orthodox thinking about war, particularly what it is and how it is fought, needs to be updated. Accelerating societal, economic, political and technological change affects how we prepare, equip and organise for war, as well as how we conduct war – both in its low-tech and high-tech forms, and whether it is with high in…
Chapter 4 is designed so as to consolidate the discussion presented in Chapters 1–3. It introduces the control-decision-innovation (CDI) model and thus concludes the process of its gradual development. The foundation of the model is derived from the complex, and therefore challenging, nature of innovation system management and control. Consequently, it demonstrates that a direct link between …
In this landmark Companion, expert contributors from around the world map out the field of the critical medical humanities. This is the first volume to introduce comprehensively the ways in which interdisciplinary thinking across the humanities and social sciences might contribute to, critique and develop medical understanding of the human individually and collectively
Facilitation cascades occur when a habitat-forming species facilitates another habitat-forming species with synergistic effects on biodiversity. This review summarizes the current state of knowledge of facilitation cascades in marine environments, describing (1) the geographic distribution of studies documenting facilitation cascades; (2) the range of habitats and organisms involved; (3) the…
Coastal wetlands such as mangrove forests and salt marshes provide a range of important benefits to people, broadly defined as ecosystem services. These include provisioning services such as fuelwood and food, regulating services such as carbon sequestration and wave attenuation, and various tangible and intangible cultural services. However, strong negative perceptions of coastal wetlands …
The purpose of this chapter is to introduce a novel mixed-methods framework design for large-scale literature reviews which can encompass thousands of publications, including an entire scientific field, referred to as the Systematic Science Mapping (SSM) Framework. The SSM Framework establishes a “big picture” or macro view of a field of inquiry’s evolution, a thematic analysis of the…
While quantitative approaches seek to make certain contents measurable, for example through word counts or reliable categorization (coding) of longer text sequences, qualitative social researchers put more emphasis on systematic ways to generate a deep understanding of social phenomena from text.
Chaos theory is an interdisciplinary area of scientific study and a branch of engineering focused on the law of dynamic systems. Even very accurate measurements of the current state of a chaotic system become useless indicators of where the system will be. Many approaches to nonlinear dynamics such as the Fast Fourier Transform (FFT), phase-plane diagram, Poincaré map, bifurcation diagram, and…