The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of …
This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical p…
This title provides a point-of-care reference for busy clinicians who need the best evidence based answers to patient questions at their fingertips. Additionally, it guides clinicians through the complicated therapeutic management of IBD including drug initiation, medications side effects and complications, therapeutic level monitoring and accurate disease monitoring. Lastly, it addresses speci…
This book presents a study in knowledge discovery in data with knowledge understood as a set of relations among objects and their properties. Relations in this case are implicative decision rules and the paradigm in which they are induced is that of computing with granules defined by rough inclusions, the latter introduced and studied within rough mereology, the fuzzified version of mereology. …
This book examines how information systems research and education can play a major role in contributing to solutions to the Societal Grand Challenges formulated in “The Millennium Project” (millenium-project.org). Individual chapters focus on specific challenges, review existing approaches and contributions towards solutions in information systems research and outline a research agenda for …
This book reports significant progress of scientific research on horseshoe crabs, including aspects of evolution, genetics, ecology, population dynamics, general biology and physiology, within the recent 10 years. It also highlights the emerging issues related to world-wide conservation threats, status and needs. The contributions in this book represent part of an ongoing global effort to incre…
This book proposes a novel approach for time-series prediction using machine learning techniques with automatic feature generation. Application of machine learning techniques to predict time-series continues to attract considerable attention due to the difficulty of the prediction problems compounded by the non-linear and non-stationary nature of the real world time-series. The performance of m…
This book is a systematized overview of wild edible plants eaten in the territory of present Estonia, with a focus on the systematic changes within the field. Starting in the end of 18th century, when the first data was published, the text is an extended version and compilation of articles on the subject published by Drs. Kalle and Sõukand and includes unpublished fieldwork results. This work …
This volume presents recent research, challenging problems and solutions in Intelligent Systems– covering the following disciplines: artificial and computational intelligence, fuzzy logic and other non-classic logics, intelligent database systems, information retrieval, information fusion, intelligent search (engines), data mining, cluster analysis, unsupervised learning, machine learning, in…
This is a deliberately provocative book. It critiques current student behaviour management practices, seeks to explain the flawed assumptions that justify those practices, and proposes how things could be better for children in our schools if different practices were adopted. It is one of the few books to offer alternative ways of addressing the issues associated with student behaviour at schoo…