This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correla…
This book explores the emergence of epilepsy as a purely neurological disorder, in the second half of the nineteenth century. It focuses on the world’s first neurological hospital, the National Hospital for the Paralysed and Epileptic in London, and on its leading figure, John Hughlings Jackson (1835-1911). Through an analysis of the National Hospital’s medical records and a historical acco…
These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic.
The book provides fundamental new insights in the structure and function of the healthy NeuroMuscular system. Recent findings suggest that the musculoskeletal system that supports movement control on Earth is controlled by unique principles of structural, biochemical and molecular characteristics. Mechanical loading by working against normal gravity helps to support principal structures in bon…
Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. Th…
This book presents new findings that deal with different facets of the well-being of children and their relevance to the proper treatment of children. The well-being of children is considered against the background of a wide variety of legal, political, medical, educational and familial perspectives. The book addresses diverse issues from a range of disciplinary perspectives using a variety of …
Sarah Carter reveals the pioneering efforts of the government, legal, and religious authorities to impose the “one man, one woman” model of marriage upon Mormons and Aboriginal people in Western Canada. This lucidly written, richly researched book revises what we know about marriage and the gendered politics of late 19th century reform, shifts our understanding of Aboriginal history during …
With a sure voice, Groulx, an Anishnaabe writer, artistically weaves together the experiences of Indigenous peoples in settler Canada with those of the people of Palestine, revealing a shared understanding of colonial pasts and presents.
In 1670, the ancient homeland of the Cree and Ojibwe people of Hudson Bay became known to the English entrepreneurs of the Hudson’s Bay Company as Rupert’s Land, after the founder and absentee landlord, Prince Rupert. For four decades, Jennifer S. H. Brown has examined the complex relationships that developed among the newcomers and the Algonquian communities—who hosted and tolerated the …
This book focuses on solving different types of time-varying problems. It presents various Zhang dynamics (ZD) models by defining various Zhang functions (ZFs) in real and complex domains. It then provides theoretical analyses of such ZD models and illustrates their results. It also uses simulations to substantiate their efficacy and show the feasibility of the presented ZD approach (i.e., diff…