This book examines in detail the planning and modelling of local infrastructure like energy systems, including the complexities resulting from various uncertainties. Readers will discover the individual steps involved in infrastructure planning in cities and territories, as well as the primary requirements and supporting quality factors. Further topics covered concern the field of uncertainty a…
This book integrates multiple criteria concepts and methods for problems within the Risk, Reliability and Maintenance (RRM) context. The concepts and foundations related to RRM are considered for this integration with multicriteria approaches. In the book, a general framework for building decision models is presented and this is illustrated in various chapters by discussing many different decis…
End-of-life issues in cardiology are becoming increasingly important in the management of patients in the cardiac unit, but there is frequently a lack of understanding regarding their impact on cardiology practice. The cardiac unit is increasingly becoming the location whereby a number of key clinical decisions relating to end-of-life care are being made, such as the decision to remove medicati…
Psychopharmacology is the study of the effects of psychoactive drugs on the functioning of the central nervous system at all levels of analysis, thus embracing cognition, behavior, psychological states, neurophysiology, neurochemistry, gene expression, and molecular biology. It includes, as an integral part of its domain, the interaction of environmental and genetic factors with psychoactive dr…
Are you looking for new lectures for your course on algorithms, combinatorial optimization, or algorithmic game theory? Maybe you need a convenient source of relevant, current topics for a graduate student or advanced undergraduate student seminar? Or perhaps you just want an enjoyable look at some beautiful mathematical and algorithmic results, ideas, proofs, concepts, and techniques in disc…
This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients ac…
This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer co…
This book shows how transit assignment models can be used to describe and predict the patterns of network patronage in public transport systems. It provides a fundamental technical tool that can be employed in the process of designing, implementing and evaluating measures and/or policies to improve the current state of transport systems within given financial, technical and social constraints. …
This book is devoted to recent developments and applications of multiple criteria decision aid tools in the field of finance, insurance and investment. It illustrates recent methods and procedures designed to solve problems related to finance, insurance and portfolio selection formulated through a mathematical programming framework and for which a large number of conflicting and incommensurable…
The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug d…