This brief goes back to basics and describes the Quantitative structure-activity/property relationships (QSARs/QSPRs) that represent predictive models derived from the application of statistical tools correlating biological activity (including therapeutic and toxic) and properties of chemicals (drugs/toxicants/environmental pollutants) with descriptors representative of molecular structure and/…
This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against…
Time series analysis and modelling represent a large study field, implying the approach from the perspective of the time and frequency, with applications in different domains. Modelling hydro-meteorological time series is difficult due to the characteristics of these series, as long range dependence, spatial dependence, the correlation with other series. Continuous spatial data plays an importa…
This book is an introduction to the theory of Hilbert space, a fundamental tool for non-relativistic quantum mechanics. Linear, topological, metric, and normed spaces are all addressed in detail, in a rigorous but reader-friendly fashion. The rationale for an introduction to the theory of Hilbert space, rather than a detailed study of Hilbert space theory itself, resides in the very high mathem…
This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeuti…
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genom…
This book is a concise introduction to electromagnetics and electromagnetic fields that covers the aspects of most significance for engineering applications by means of a rigorous, analytical treatment. After an introduction to equations and basic theorems, topics of fundamental theoretical and applicative importance, including plane waves, transmission lines, waveguides and Green's functions, …
Fluorescence is the most popular technique in chemical and biological sensing and this book provides systematic knowledge of basic principles in the design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Its ultimate sensitivity, high temporal and spatial resolution and versatility enables high resolution imaging within living cells. It dev…
“This concise review of current issues and advances in the field of urologic pathology incorporates the histological, genetic, and clinical aspects. … This book is readily accessible to residents, general pathologists, and specialists in the field of urologic pathology. … This is an eminently accessible book for practicing pathologists and it is a useful reference for many of the day-to-d…
This book reports on a novel and comprehensive approach to the uptake of ICT in Schools. It focuses on key questions, pedagogically sound ways of introducing ICT, new technical artifacts supporting the approach, the evaluation in a large-scale validator, and future work. While many innovations in Technology Enhanced Learning (TEL) have emerged over the last two decades, the uptake of these inno…