This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
This book calls for the conditions of transition to sustainability: How to take into consideration new global phenomena such as and of the dimension of climate change, the depletion of natural resources, financial crises, demographic dynamics, global urbanization, migrations and mobility, while bearing in mind short-term or local place-based issues, such as social justice or quality of life? Me…
This book examines the kinds of transitions that have been studied in mathematics education research. It defines transition as a process of change, and describes learning in an educational context as a transition process. The book focuses on research in the area of mathematics education, and starts out with a literature review, describing the epistemological, cognitive, institutional and socioc…
Astrid Bothmann examines historical, political and socioeconomic factors that explain the absence of transitional justice in Nicaragua from 1990 to 2012. The author provides the first systematic analysis of the reasons for the lack of transitional justice in Nicaragua after the end of the Sandinista regime and the civil war (1990). Contrary to other Latin American states of the third wave of de…
This is the first English book that presents a professional analysis of the recent dynamic movement of the Chinese economy by focusing on the Yangtze River Delta region, which is the main engine of the Chinese economy. The impact of the international financial crisis on China’s economic development requires a change from the first wave of economic globalization oriented toward exports to the …
This book conveys the story of a society in the throes of restructuring itself and struggling to find a new identity. A particularly attractive aspect of this study is the focus on young adult literature and its place in post-apartheid South Africa, as well as its potential use in the classroom and lecture hall. Intersecting these two topics provides a compelling lens for refocusing debate on …
Transitional Urology is designed to fill a critical gap that exists in the published literature by comprehensively addressing the urological challenges facing adolescents and adults with complex congenital anomalies of the genitourinary system. It provides a valuable resource to pediatricians and pediatric urologists facing urological management issues beyond their expertise in their aging pat…
This thesis examines various aspects of excess excitation energy dissipation via dynamic changes in molecular structure, vibrational modes and solvation. The computational work is carefully described and the results are compared to experimental data obtained using femtosecond spectroscopy and x-ray scattering. The level of agreement between theory and experiment is impressive and provides both …
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
This book presents lessons learnt from Japan’s past, in relation to coastal waters, industrial pollutants and concentrated urban populations. It examines ecosystem damage and pollution in coastal sea areas and addresses the question: What is the present status of Japanese estuaries from the view point of eutrophication and oligotrophication? The authors describe three typical situations, name…