The renin angiotensin system is implicated in the progression of atherosclerotic disease as well as of left ventricular dysfunction. Angiotensin converting enzyme inhibitors and AT1 receptor antagonists have been proven to reduce morbidity and mortality in patients with left ventricular dysfunction or in those at high cardiovascular risk with preserved ventricular function. This book is intende…
Gerhard Gentzen has been described as logic’s lost genius, whom Gödel called a better logician than himself. This work comprises articles by leading proof theorists, attesting to Gentzen’s enduring legacy to mathematical logic and beyond. The contributions range from philosophical reflections and re-evaluations of Gentzen’s original consistency proofs to the most recent developments in p…
This book focuses on partitional clustering algorithms, which are commonly used in engineering and computer scientific applications. The goal of this volume is to summarize the state-of-the-art in partitional clustering. The book includes such topics as center-based clustering, competitive learning clustering and density-based clustering. Each chapter is contributed by a leading expert in the f…
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within wh…
Based on a large action research project, this book elaborates on how genre-based pedagogy can be extended to engage non-English speaking background students in tertiary educational institutions to develop their academic literacy practice, using online resources.
Focusing on the recent proliferation of Wi-Fi in hospital systems, this book explains how Wi-Fi is transforming clinical work flows and infusing new life into the types of mobile devices being implemented in hospitals. Drawing on years of consulting with hospitals in the US and abroad, and with first-hand experiences from one of the largest healthcare systems in the United States, it covers the…
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emergin…
https://openresearchlibrary.org/content/ab365bcc-0200-450b-8a0d-8ce9dd964d45
The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clin…
Drawing on anthropology, historical sociology and social-epidemiology, this multidisciplinary book investigates how pharmaceuticals are produced, distributed, prescribed, (and) consumed, and regulated in order to construct a comprehensive understanding of the issues that drive (medicine) pharmaceutical markets in the Global South today. Based on primary research conducted in Benin and Ghana,…