Le but du livre est de définir et développer une grande gamme d'outils probabilistes pour la modélisation en biologie des populations, afin de décrire des dynamiques temporelles de quantités biologiques telles que la taille d'une ou plusieurs populations, la proportion d'un allèle dans une population ou la position d'un individu. En partant de modèles markoviens discrets (marches alé…
This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological reg…
This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and r…
This book covers layout design and layout migration methodologies for optimizing multi-net wire structures in advanced VLSI interconnects. Scaling-dependent models for interconnect power, interconnect delay and crosstalk noise are covered in depth, and several design optimization problems are addressed, such as minimization of interconnect power under delay constraints, or design for minimal de…
This book covers three fundamental problems at the interface of multi-project management and human resource management: the selection of projects, the composition of small project teams, and workload leveling. Matthias Walter proposes optimization models and solution methods for these problems, assuming multi-skilled workers with heterogeneous skill levels. For the first time, the author presen…
Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the t…
Governing universities is a multi-level as well as a highly paradoxical endeavor. The featured studies in this book examine critically the multifaceted repercussions of changing governance logics and show how contradictory demands for scholarly peer control, market responsiveness, public policy control, and democratization create governance paradoxes. While a large body of academic literature h…
The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are…
This monograph presents new developments in multi-level decision-making theory, technique and method in both modeling and solution issues. It especially presents how a decision support system can support managers in reaching a solution to a multi-level decision problem in practice. This monograph combines decision theories, methods, algorithms and applications effectively. It discusses in de…
This book focuses on a large class of geometric objects in moduli theory and provides explicit computations to investigate their families. Concrete examples are developed that take advantage of the intricate interplay between Algebraic Geometry and Combinatorics. Compactifications of moduli spaces play a crucial role in Number Theory, String Theory, and Quantum Field Theory – to mention just …