Designing immunotherapeutics, drugs, and anti-inflammatory reagents has been at the forefront of autoimmune research, in particular, multiple sclerosis, for over 20 years. Delivery methods that are used to modulate effective and long-lasting immune responses have been the major focus. This Special Issue, “Advances in Multiple Sclerosis Research—Series I”, focused on delivery methods u…
Pioglitazone has been reported in the literature to have a substantial role in the improvement of overall cognition in a mouse model. With this in mind, the aim of this study was to determine the most efficacious route for the administration of Pioglitazone nanoparticles (PGZ-NPs) in order to promote drug delivery to the brain for the treatment of Alzheimer’s disease. PGZ-loaded NPs were …
Deregulation of signalling pathways that regulate cell growth, survival, metabolism, and migration can frequently lead to the progression of cancer. Brain tumours are a large group of malignancies characterised by inter- and intratumoral heterogeneity, with glioblastoma (GBM) being the most aggressive and fatal. The present study aimed to characterise the expression of cancer pathway-relate…
Molecular vegetable breeding has been progressed intensively in recent years. Huge advances have been made in germplasm evaluation, gene isolation, plant transformation, gene editing and molecular-marker-assisted breeding. The goal of this Special Issue is to highlight, through selected works, frontier research from basic to applied molecular vegetable breeding
To be human is to care how the physical world came, whether it has boundaries and what is to become of it. Cosmology is the science that tries to answer these eternal questions. During the twentieth century, it has been elevated from the rank of philosophy to precision science thanks to the advances in both theory and observation. General relativity, quantum mechanics and observational tech…
Precipitation is the most important variable in the climate system and the dominant driver of land surface hydrologic conditions. Rain gauge measurement provides precipitation estimates on the ground surface; however, these measurements are sparse, especially in the high-elevation areas of Nepal. Reanalysis datasets are the potential alternative for precipitation measurement, although it mu…
Fast urbanization and industrialization have progressively caused severe impacts on mountainous, river, and coastal environments, and have increased the risks for people living in these areas. Human activities have changed ecosystems hence it is important to determine ways to predict these consequences to enable the preservation and restoration of these key areas. Furthermore, extreme event…
Pressure and flowrate measurements were conducted for an air-cooled salient pole hydro model generator in order to validate a computational fluid dynamics (CFD) simulation approach. The ventilation system of the model generator was driven by adjustable external fans, which allows detailed pressure measurements for a range of operating conditions. The CFD model to be validated consists of fu…
Although fluid dynamics, a classical discipline, has been studied for many centuries, there are still many remaining questions yet to be answered, especially in turbulent flow. With significant advances in computational technology and decrease hardware costs, we have noticed a rapid evolution in CFD techniques and models
This Editorial presents a representative collection of 15 papers, presented in the Special Issue on Advances in Modeling and Management of Urban Water Networks (UWNs), and frames them in the current research trends. The most analyzed systems in the Special Issue are the Water Distribution Systems (WDSs), with the following four topics explored: asset management, modelling of demand and hydr…