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Molecular Structures and Structural Dynamics of Prion Proteins and Prions
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by…
- Edition
- 1
- ISBN/ISSN
- 978-94-017-7317-1
- Collation
- XIX, 355
- Series Title
- Focus on Structural Biology
- Call Number
- -
Modified Nucleic Acids in Biology and Medicine
This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. …
- Edition
- 1
- ISBN/ISSN
- 2197-9758
- Collation
- XIV, 453
- Series Title
- RNA Technologies
- Call Number
- -
Molecular Mechanisms of Cell Differentiation in Gonad Development
This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of th…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-31971-1
- Collation
- XII, 434
- Series Title
- Results and Problems in Cell Differentiation
- Call Number
- -
Molecular Genetics of Pediatric Orthopaedic Disorders
In the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders. A few projects have even progressed into the realm of clinical trials that are primarily aimed at controlling progressive disease. Meanwhile, genomic technology development has outpaced expectations and is enabling gene discovery for disorders that…
- Edition
- 1
- ISBN/ISSN
- 978-1-4939-2168-3
- Collation
- XII, 168
- Series Title
- Springer New York, NY
- Call Number
- -
Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytoc…
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-16008-5
- Collation
- XV, 368
- Series Title
- Advances in Experimental Medicine and Biology
- Call Number
- -
The Strategy Planning Process Analyses, Options, Projects
Developing future strategies for a company is an important and complex task, and forms the core issue in this book. A company’s strategy defines its future direction, specifying its desired market position and key competitive advantages both at the level of market offers and of resources. This book provides clear, straightforward advice for professionals: after a brief introduction to strateg…
- Edition
- -
- ISBN/ISSN
- 978-3-662-51603-4
- Collation
- -
- Series Title
- -
- Call Number
- -
The Strategy Planning Process Analyses, Options, Projects
Developing future strategies for a company is an important and complex task, and forms the core issue in this book. A company’s strategy defines its future direction, specifying its desired market position and key competitive advantages both at the level of market offers and of resources. This book provides clear, straightforward advice for professionals: after a brief introduction to strateg…
- Edition
- -
- ISBN/ISSN
- -
- Collation
- -
- Series Title
- -
- Call Number
- -
Models, Algorithms and Technologies for Network Analysis:NET 2014, Nizhny Nov…
The contributions in this volume cover a broad range of topics including maximum cliques, graph coloring, data mining, brain networks, Steiner forest, logistic and supply chain networks. Network algorithms and their applications to market graphs, manufacturing problems, internet networks and social networks are highlighted. The "Fourth International Conference in Network Analysis," held at the …
- Edition
- 1
- ISBN/ISSN
- 978-3-319-29606-7
- Collation
- XVI, 340
- Series Title
- Springer Proceedings in Mathematics & Statistics
- Call Number
- -
The Serpin Family
The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but a…
- Edition
- -
- ISBN/ISSN
- 978-3-319-22711-5
- Collation
- -
- Series Title
- -
- Call Number
- -
Military Logistics
This book highlights recent advances in the development of effective modeling and solution approaches to enhance the performance of military logistics. It seeks to further research in global defense-related topics, including military operations, governmental operations and security, as well as nation support. Additionally its purpose is to promote the global exchange of information and ideas am…
- Edition
- 1
- ISBN/ISSN
- 978-3-319-12074-4
- Collation
- XII, 172
- Series Title
- Operations Research/Computer Science Interfaces Series
- Call Number
- -
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