Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. Th…
Diabetes mellitus is a group of metabolic disorders leading to defects in insulin se- cretion and action of insulin or both. Diabetes is caused by a combination of hereditary and environmental factors. In the human body, blood glucose levels are controlled by a complex interaction of multiple chemicals and hormones, including insulin and glucagon. Insulin is a peptide hormone produced in …
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT). 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as …
This book provides an up-to-date overview of redox signaling in plant cells and its key role in responses to different stresses. The chapters, which are original works or reviews, focus on redox signaling states; cellular tolerance under different biotic and abiotic stresses; cellular redox homeostasis as a central modulator; redox homeostasis and reactive oxygen species (ROS); redox balance in…
Interest in the study of life in hot environments, both with respect to the inhabiting microorganisms and the enzymes they produce, is currently very high. The biological mechanisms responsible for the resistance to high temperatures are not yet fully understood, whereas thermostability is a highly required feature for industrial applications. In this e-book, the invited authors provide diverse…
This book describes the human amniotic membrane from its origin, characterization and medical applications, summarizing all the latest developments and findings related to this tissue with contributions from some of the leading researchers in the field. The book addresses issues for its preservation, separation and identification of amniotic membrane-derived cells, as well as the potential ethi…
The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism.…
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and…
Dr. María de Cortes Sánchez-Mata, PhD in Pharmacy, is currently a professor in Food Science at the Faculty of Pharmacy, Complutense University of Madrid, Spain. She has performed a continuous research on the analysis of nutrients, antinutrients and bioactive compounds in plant foods, with the focus on human health promotion. Dr. Javier Tardío, PhD in Agricultural Engineering, is currently…
Since ancient times, plants have been used as a prime natural source of alternative medicines and have played an important role in our lives. The old tradition of medicinal plant application has turned into a highly profitable business in the global market, resulting in the release of a large number of herbal products. People have tried to find different sources of medicines to alleviate pain a…