Latest generation sequencing revolutionizes the fields of cancer research and oncology. This follow-up volume focuses more extensively on single cell sequencing of cancer and trials in drug resistance. Another exciting feature is the bioinformatics tools given, that can be used on cancer genome studies. Scientists around the world are attempting to find the root cause of cancer. A reasonable ca…
This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genom…
This book provides an introduction to the genetics, genomics, and breeding of the olive tree, a multi-functional long-lived crop plant that is relevant not only for culinary olive and oil production, but also for shaping the landscape and history of many rural areas for centuries. Today, the recognized health benefits of extra-virgin olive oil provide new impulses for introducing innovation in …
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and …
This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. Chapters provide details of state-of-the-art methodology for rare variant detection and calling, imputation an…
The Work is an interdisciplinary research approach, combining modern genetics and genomics, traditional physiology and biochemistry, and advanced bioinformatics and crop modelling. It is a rapidly developing field and this book is testimony to its dynamic evolution. It provides examples of how gene regulatory and metabolic networks are included, in a spatially and temporally specific manner, in…
Human Genetics; Philosophy of Science; Probability Theory
Triticale crop species has received substantial research support since the mid-20th century making it a commercial success in many countries, in diverse value propositions. However, no recent book captures the new knowledge and progresses made in more than 2 decades. The purpose of this work is to review and collate the new knowledge of triticale plant biology and agronomy, while considering th…
Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabete…
On February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Göttingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Göttingen, and was generously sponsored by the Deutsche Forschungsgemeinschaft. Some forty geneticists and clinicians from Europe and N orth America, working in the field of diabetes bot…