This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
In recent years, AI/ML tools have become more prevalent in the fields of medical imaging and imaging informatics, where systems are already outperforming physicians in a range of domains, such as in the classification of retinal fundus images in ophthalmology, chest X-rays in radiology, and skin cancer detection in dermatology, among many others. It has recently emerged as one of the fastest gr…
The book collects scientific contributions aiming at describing the common mechanism, across living species, by which innate immunity interacts with nanomaterials with the goal of harnessing such interactions for improving environmental and human safety and exploiting them for modulating immunity in vaccination strategies.
"Multiple chronic conditions," also known as multimorbidity, is a special situation frequently encountered by global healthcare professionals, especially internists/primary care physicians, neurologists, respiratory/pulmonologists, pain specialists, and oncologists, who spend more than three-quarters of their time in the treatment of chronic diseases and direct patient care. Thus, the increasin…
Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources…
The latest diagnostic and therapeutic modalities in the management of coronary artery disease by coronary artery bypass graft surgery and by percutaneous coronary intervention with stenting and in the interventional management of other atherosclerotic vascular disease have led to a reduction in cardiovascular mortality and morbidity. This book entitled Artery Bypass provides an excellent update…
Arteriovenous fistulas are shunts between arteries and veins that can be found in many organs of the human body such as the brain, skin, eye and lung. These lesions can be symptomatic by causing ischemia, through the process of the steal phenomenon, or vascular congestion and subsequent hemorrhage, eg. intracerebral hemorrhage of a ruptured dural arteriovenous fistula. The etiology of these les…
Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body’s own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives …
The EURACT Performance Agenda (EUPA) of the European Academy of Teachers in General Practice/Family Medicine (EURACT) is the third paper in a row following the European Definition of General Practice/Family Medicine (WONCA Europe) in 2002 which identified 6 core competencies and 11 abilities every general practitioner (GP) should master, and the EURACT Educational Agenda in 2005 which provided …
Cancer screening is a prominent strategy in cancer control in the United States, yet the ability to correctly interpret cancer screening data eludes many researchers, clinicians, and policy makers. This open access primer rectifies that situation by teaching readers, in simple language and with straightforward examples, why and how the population-level cancer burden changes when screening is im…